Vânia Célia Vieira de Siqueira

Effects of Short- and Long-Term Celecoxib on Orthodontic Tooth Movement

OBJECTIVE To test the hypothesis that short- and long-term celecoxib administration has no effect on orthodontic tooth movement. MATERIALS AND METHODS Male Wistar rats were submitted to short- (3 days) and long-term (14 days) celecoxib administration, while the respective control groups received equivolumetric saline intraperitoneal injections. The upper left first molars of all rats were moved mesially for 14 days by a fixed orthodontic appliance exerting 50 g force upon insertion. After the experimental period, tooth movement was quantified and tissues around the first molar were processed for tartrate-resistant acid phosphatase (TRAP) histochemistry. The amount of tooth movement and the number of TRAP-positive cells on the alveolar bone surface were evaluated. RESULTS The amount of tooth movement was significantly reduced in rats submitted to short- and long-term celecoxib administration, while the number of osteoclasts on the alveolar bone did not differ between the four groups studied. CONCLUSIONS The hypothesis is rejected. Although celecoxib administration did not affect the number of osteoclasts, the osteoclast activity might be reduced, which could explain the inhibition of tooth movement observed in the celecoxib-treated animals. These results indicate that orthodontists should be aware of patients under short- and long-term therapy with celecoxib.

Avaliação do ângulo nasolabial após o tratamento ortodôntico com e sem extração dos primeiros pré-molares

AIM: To cephalometrically evaluate the changes in the nasolabial angle of the patients submitted to orthodontic treatment with and without extractions and correlate them with upper incisor inclination, upper lip position and the base of the nose. METHODS: The sample was composed of pre and posttreatment lateral cephalometric records of 30 female patients with Class II division 1 malocclusion. Fifteen were treated with first premolars extractions and the other fifteen without extractions. The following parameters were measured: nasolabial angle; upper incisor inclination (Is.SN7o angle), upper lip position (Ls-PCm.SN7o angle) and base of the nose (PCm.SN7o angle). RESULTS: The upper incisor inclination and the upper lip position showed a statistically significant increase from T0 to T1 in the extraction group. No statistically significant differences were found for the other parameters in both groups. The correlations between upper lip position, base of the nose and the nasolabial angle were positive. CONCLUSION: 1) There was a significant increase in the nasolabial angle in the extraction group and it was mainly due to changes in the upper lip position; 2) nasal growth during the study period did not contributed to the nasolabial angle increase; 3) all measurements were not statistically different between the 2 groups at T0 and T1, and 4) a positive correlation was found between the nasolabial angle, lip position and base of the nose in both groups.

Estudo cefalométrico das características ântero-posteriores em jovens com dentadura decídua

AIM: the aim of this study was to evaluate the antero-posterior cephalometric characteristics in children until primary dentition. METHODS: a group of 42 males, who had normal primary dentition, divided in two groups, one of four year-old boys (n=22) and the other of boys with five years old (n=20), were evaluated to determine cephalometric norms. Simultaneously, groups were evaluated to obtain information about the facial growth on those age. The measurements were taken on lateral cephalograms. Only those who had normal primary dentition and balanced profiles were selected. The cephalometric measurements were SNA, SNB, ANB, SN.GoGn, 1.1, FMA, FMIA and IMPA and linear measurements Nperp-A, Co-A, Co-Gn, maxillomandibular differential, S-N, ENA-ENP, overjet and ramus height. The Students t test, with significance level of 5%, was used to detect differences between the groups. RESULTS AND CONCLUSIONS: differences were detected only for angular measurements that involved the lower incisor (IMPA and 1.1). G2 individuals had their incisors more uprighted in their jaws than G1. All the linear measurements in G2 were higher than those in G1, but only Co-A, Co-Gn, and maxillomandibular differential presented a statistical significant difference.

O efeito da alteração da posição natural da cabeça (PNC) sobre as medidas cefalométricas

This work aimed to study the alterations of angular and linear cephalometrics measurements used in cephalometry, when the natural head position (NHP) is modified during the taking of cephalometric radiography, its influence in the orthodontic diagnosis, and the reliability and reproducibility of NHP for successive radiographs. One hundred and eighty cephalometrics radiographs were taken in lateral norm of 30 female patients with age range of 21,3 years old. The X-ray were obtained in two series within 15 days interval among them. In each of the series, the natural head position (NHP), the NHP added of 5 degrees (NHP+5o) and NHP with 5 degrees of flexion (NHP-5o) were registered from each patient. The obtained results demonstrated that the linear measurements S-N, ENA-ENP, Co-Gn, Go-Gn, and the angular measurements SNA, ANB, PP.GoGn, 1.PP, IMPA, 1.1, SN.VER and HF.VER did not present statistically significant alterations among the studied positions and the two series of radiographic taken as well. The angular measurements of SNB, SN.GoGn, FMA, SN.PP, Z Angle, Co-Go presented statistically significant alterations. It was concluded that the angular and linear measurements appraised did not present significant alterations when the NHP modified within of the angular variation strip studied, which did not lead to doubtful diagnosis or interpretations. Due to low variation of the angulations of the SN.VER and HF.VER angles, it was demonstrated that the employment of the Guiding Unit of Positioning presented in this work, allows the reproducibility of the natural head position with great reliability within a + 5o variation strip of NHP.

Efeitos do tratamento da Classe II divisão 1 em pacientes dolicofaciais tratados segundo a Terapia Bioprogressiva (AEB cervical e arco base inferior), com ênfase no controle vertical

OBJECTIVE: This study investigated vertical control and the effects of orthodontic treatment on dolichofacial patients, using cervical headgear (CHG) and lower utility arch. METHODS: Cephalometric assessment of 26 dolichofacial patients with Class II, division 1, and mean age of 114 months. Orthodontic treatment involved the use of cervical headgear (CHG) in the maxillary arch, lower utility arch in the mandibular arch until normal occlusion of the molars was obtained and finished in accordance with Bioprogressive therapy, with a mean duration of 56 months. The values of FMA, SN.GoGn, ANB, Fg-S, S-FPm, maxillary length, mandibular length, posterior facial height (PFH), anterior facial height (AFH), facial height index (FHI), occlusal plane angle (OPA), palatal plane angle (PPA), total chin (TC), upper lip (UL) and Z angle were evaluated. RESULTS: The results showed that treatment promoted stability of the mandibular, occlusal and palatal planes. Anteroposterior correction of the apical bases occurred, verified by the significant reduction in the variable ANB. The maxilla presented slight anterior displacement and increase in the anteroposterior dimension. The mandible presented improvement in its position in relation to the cranial base and its anteroposterior dimension increased significantly. The posterior and anterior facial heights remained in equilibrium, with no significant alteration in FHI. The tegumental profile presented significant improvement. CONCLUSION: The treatment performed produced correction of the apical basis with control of the horizontal planes and facial heights, and was effective for vertical control.

A relação entre o crescimento mandibular e a maturação esquelética em jovens brasileiras melanodermas

Objective: To assess the degree of correlation between mandibular growth and skeletal maturation in young melanodermic Brazilian women. Methods: The authors examined 140 lateral cephalometric radiographs and an additional 140 radiographs of hands and wrists of young female Brazilian melanodermic subjects aged 8 to 14 years with normal occlusion or Angle Class I malocclusion, who had not been subjected to previous orthodontic treatment. Using the hand and wrist radiographs, the authors evaluated the development of ossification centers in the proximal phalanx of the 3rd finger and the distal epiphysis of the radius bone, by tracing according to the method described by Eklof and Ringertz. The lateral cephalometric radiographs enabled an analysis of frontal sinus pneumatization according to the method described by Ruf and Pancherz, and of the cephalometric measurements representative of mandibular growth, namely, Co-Go, Co-Gn, Go-Gn, Fg-Pg. The data were statistically analyzed using Pearson’s Correlation to determine the degree of relationship between variables. Results and Conclusions: A highly significant correlation was found between ossification centers observed on the hand and wrist radiographs and cephalometric measurements representative of the mandibular growth (r = 0.777). Although statistically significant, there was a low correlation between frontal sinus pneumatization and the progression of skeletal maturity (r = 0.306), as well as a relationship between frontal sinus pneumatization and the cephalometric measurements representative of mandibular growth (r = 0.218).