Victor Snieckus

Combined directed metalation - cross coupling strategies. Total synthesis of the aglycones of gilvocarcin V, M and E

Abstract Using the versatile Directed ortho and remote Metalation protocols linked with Suzuki-Miyaura cross coupling, efficient syntheses of defucogilvocarcin V, M, and E, 2–4 have been achieved.

4,6-DIMETHOXY-3,7-DIMETHYLCOUMARIN FROM COLCHICUM DECAISNEI. TOTAL SYNTHESIS BY CARBAMOYL BAKER-VENKATARAMAN REARRANGEMENT AND STRUCTURAL REVISION TO ISOEUGENETIN METHYL ETHER

Abstract Coumarin ( 1 ), the putative natural product isolated from Colchicum decaisnei, has been shown, by spectroscopic analysis and total synthesis, to be isoeugenetin methyl ether ( 2a ), a synthetic derivative of the isoeugenetin ( 2b ), isolated from Eugenia carvophyllata .

Synthetic Connections to the Directed ortho Methalation Reaction. 3,4-Pyridynes from 4-Trialkylsilyl-3-pyridyl Triflates

4-Trialkylsilyl-3-pyridyl triflates (11a-b), derived from 9 and 12 by directed ortho metalation chemistry, serve as useful precursors of 3,4-pyridynes (6a-b) and lead by cycloaddition and nucleophilic trapping reactions to products (13a-b, 14a-b, 15, 16a-b, and 17a-b)

Directed 2-Methalation of N,N-diethyl O-3-(4-Trimethylsilyl)pyridyl Carbamate. A Silocon Protection Route for Highly Substituted Pyridines

LiTMP metalation of N,N-diethyl 0-3-(4-trimethylsilyl)pyridyl carbamate (4) followed by quenching with a number of carbon and heteroatom electrophiles affords a variety of 2-substituted pyridine derivatives (5) (Table 2) thus providing a versatile new methodology for the synthesis of polysubstituted pyridines

Construction of Polyarylated Fluorenones via chemoselective Ru- and Pd-Catalyzed Suzuki Cross-Coupling Reactions

The importance of fluoren-9-one (1), found in many biologically active products, 1,2 has been emphasized in organic chemistry. It consists of essential structural backbone of various pharmaceuticals. Also number of natural products have been found containing fluoren-9-ones showing a range of biological acitivities; e.g. dengibsin, dengobsinin, dendroflorin and kinobscurinone. Utility of fluorenone derivatives as photosensitizers in organic photoconductor devices and their electrical and optical properties are also important. 3