Virendra Kumar

Synthesis of methyl 2,3,6-trideoxy-3-(dimethylamino)-β-L-xylo-hexopyranoside

Abstract The title amino sugar was synthesized in six steps from methyl 4,6-O-benzylidene-2,3,-dideoxy-3-trifluoroacetamido-α- d -arabino-hexopyranoside in a route based on Hortons synthesis of 3-amino-2,3,6-trideoxy sugars, but modified to avoid the problem of anhydro bridge formation. This modification was successful and all steps in the synthesis, except the final catalytic reduction, went cleanly in good to excellent yields.