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Dive into the research topics where Virgil L. Styles is active.

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Featured researches published by Virgil L. Styles.


Synthetic Communications | 2001

A CONVENIENT SYNTHESIS OF THIOFIBRATE ANALOGS FROM ARYL SULFONYL CHLORIDES

Eric E. Boros; Istvan Kaldor; Peter J. Brown; Virgil L. Styles

An expedient synthesis of pharmacologically relevant thioisobutyric acid esters from aryl sulfonyl chlorides is described.


Journal of Medicinal Chemistry | 2003

Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity.

David L. Musso; Felicia R. Cochran; James L. Kelley; Ed W. McLean; Jeffrey L. Selph; Greg C. Rigdon; G. Faye Orr; Ronda Davis; Barrett R. Cooper; Virgil L. Styles; James B. Thompson; William R. Hall


Journal of Medicinal Chemistry | 1992

2-Acetylpyridine thiocarbonohydrazones : potent inactivators of herpes simplex virus ribonucleotide reductase

Todd Andrew Blumenkopf; Joan A. Harrington; Cecilia S. Koble; Donald D. Bankston; Robert W. Morrison; Eric C. Bigham; Virgil L. Styles; Thomas Spector


Journal of Heterocyclic Chemistry | 1995

7‐(2‐fluorobenzyl)‐4‐(substituted)‐7‐H‐imidazo[4,5‐d −1,2,3‐triazines and −7H‐pyrazolo[3,4‐d]‐1,2,3‐triazines. Synthesis and anticonvulsant activity

James L. Kelley; David Wilson; Virgil L. Styles; Francis E. Soroko; Barrett R. Cooper


Journal of Medicinal Chemistry | 2003

Neuromuscular Blocking Activity and Therapeutic Potential of Mixed-Tetrahydroisoquinolinium Halofumarates and Halosuccinates in Rhesus Monkeys

Eric E. Boros; Vicente Samano; John A. Ray; James B. Thompson; David K. Jung; Istvan Kaldor; Cecilia S. Koble; Michael Tolar Martin; Virgil L. Styles; Robert A. Mook; Paul L. Feldman; John J. Savarese; Matthew R. Belmont; Eric C. Bigham; G. Evan Boswell; Mir Hashim; Sanjay Patel; James C. Wisowaty; Gary D. Bowers; Caroline L. Moseley; John S. Walsh; Mindy J. Reese; Randy D. Rutkowske; and Andrea M. Sefler; Timothy D. Spitzer


Journal of Heterocyclic Chemistry | 1995

Synthesis and anticonvulsant activity of 3H-imidazo[4,5-c]-pyridazine, 1H-imidazo[4,5-d]pyridazine and 1H-benzimidazole analogues of 9-(2-fluorobenzyl)-6-methylamino-9H-purine

James L. Kelley; James B. Thompson; Virgil L. Styles; Francis E. Soroko; Barrett R. Cooper


Journal of Organic Chemistry | 1982

Pyrimido[4,5-c]pyridazines. 3. Preferential formation of 8-amino-1H-pyrimido[4,5-c]-1,2-diazepin-6(7H)-ones by cyclizations with .alpha.,.gamma.-dioxo esters

W. Revill Mallory; Robert W. Morrison; Virgil L. Styles


Journal of Heterocyclic Chemistry | 1995

SYNTHESIS OF 5-(4-SUBSTITUTED BENZYL)-2,4-DIAMINOQUINAZOLINES AS INHIBITORS OF CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE

G. Erik Jagdmann; Joseph H. Chan; Virgil L. Styles; Robert L. Tansik; Christine M. Boytos; Sharon K. Rudolph


Journal of Organic Chemistry | 1978

Pyrimido[4,5-c]pyridazines. 1. Cyclizations with .alpha.-keto esters

Robert W. Morrison; W. Revill Mallory; Virgil L. Styles


Journal of Heterocyclic Chemistry | 2000

An improved synthesis of 2‐amino‐5‐[(4‐chlorophenyl)thio]‐4‐morpholinopyrimidine (BW 394U) — A potential antisenility agent

Vicente Samano; Virgil L. Styles; Joseph H. Chan

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