Virgil V. Herring

Effect of NaCl and Desoxycorticosterone on Body Weight and Carbohydrate Stores of Adrenalectomized Rats.

Summary Adrenalectomized rats given a 1% solution of sodium chloride to drink ad libitum in place of tap water for a 10-day period after operation gain in weight and are able to store fed glucose in amounts comparable to that of adrenalectomized rats given 0.5 mg desoxycorticosterone daily or to that of rats in which the adrenals are intact.

Effect of adrenocorticotropic hormone on the insulin content of the rat's pancreas

Summary Treatment with purified adrenocorticotropic hormone for 14 days has been found to increase the insulin content of the pancreas of hypophysectomized rats. The previously observed action of the lactogenic hormone has been confirmed.

Salt After Adrenalectomy. I. Growth and Survival of Adrenal-ectomized Rats Given Various Levels of NaCl.∗

Summary A daily intake of 650 to 940 mg NaCl for an adult adrenalectomized rat seems to be “optimal” in maintaining growth and apparent health. A daily intake of 339 mg is not sufficient for growth or survival. Large amounts of NaCl such as 1200 mg a day are injurious.

Changes in Excretion of Radioactive Na, K and in Carbohydrate Stores Twenty-four Hours following Adrenalectomy.

Summary An increased urinary excretion of sodium, and a urinary retention of potassium are detectable in 24 hours after adrenalectomy. Simultaneous with these changes, there is found a lowered blood sugar, and lowered liver, and muscle glycogen values.

Salt after Adrenalectomy. III. Carbohydrate Stores in Adrenal-ectomized Rats Given Various Levels of Sodium Chloride.

Summary The adrenalectomized rat given 650-940 mg NaCl daily stores fed glucose as liver glycogen almost as well as does an intact animal. A NaCl intake of 1200 mg seems to interfere with glycogen storage in both adrenalectomized and intact animals.

Salt After Adrenalectomy. IL Urinary Excretion of Radioactive Na and K in Adrenalectomized Rats Given Various Levels of Salt.

Summary The administration of sodium chloride to adult adrenalectomized rats in amounts varying from 650 mg to 1 g daily prevents the urinary sodium wastage and potassium retention which characterizes adrenalectomized animals.