Evelyn Anderson

Adrenal Cortical Hormone (Cortin) in Blood and Urine of Patients with Cushing's Disease.

Conclusion Patients with Cushings disease have in their blood an excess amount of a substance which resembles adrenal cortical hormone in its ability to prolong the life of the adrenalectomized rat. Furthermore, this substance is excreted in significant amounts by the kidneys.

Effect of Growth Hormone on Glycosuria of Fed Partially Depancreatized Rats.

Conclusions It has been shown that a purified growth hormone preparation of the anterior pituitary which is practically free of lactogenic, adrenocorticotropic, thyrotropic, and gonadotropic hormones, produces a marked increase in glucose excretion in the sucrose-fed partially depancreatized rat.

Effect of NaCl and Desoxycorticosterone on Body Weight and Carbohydrate Stores of Adrenalectomized Rats.

Summary Adrenalectomized rats given a 1% solution of sodium chloride to drink ad libitum in place of tap water for a 10-day period after operation gain in weight and are able to store fed glucose in amounts comparable to that of adrenalectomized rats given 0.5 mg desoxycorticosterone daily or to that of rats in which the adrenals are intact.

Urinary Excretion of Radioactive Na and K in Adrenalectomized Rats, With and Without Salt.

Summary (1) Radioactive isotopes of sodium and potassium furnish a new method of study of the physiology of the adrenal cortex. (2) Adrenalectomized rats, unsupported by salt treatment, have an increased total sodium excretion and increased rate of excretion of administered radioactive sodium when contrasted with normal animals; the reverse is true of potassium. (3) Simple access to a 1% solution of table salt enables adrenalectomized rats to handle sodium and potassium in a way resembling that of normal rats.

Salt After Adrenalectomy. I. Growth and Survival of Adrenal-ectomized Rats Given Various Levels of NaCl.∗

Summary A daily intake of 650 to 940 mg NaCl for an adult adrenalectomized rat seems to be “optimal” in maintaining growth and apparent health. A daily intake of 339 mg is not sufficient for growth or survival. Large amounts of NaCl such as 1200 mg a day are injurious.

Changes in Excretion of Radioactive Na, K and in Carbohydrate Stores Twenty-four Hours following Adrenalectomy.

Summary An increased urinary excretion of sodium, and a urinary retention of potassium are detectable in 24 hours after adrenalectomy. Simultaneous with these changes, there is found a lowered blood sugar, and lowered liver, and muscle glycogen values.

Electrolyte Excretion Studies in Rats Maintained on Low-Na and Low-K Diets.

Summary (1) Rats which have been reared on a low-sodium diet excrete radioactive sodium more rapidly than normal rats, and retain radioactive potassium in greater amounts than normal. In this respect they resemble untreated adrenalectomized rats. The giving of cortin corrected this disturbance. (2) Rats deficient in potassium excrete radioactive sodium at a normal rate but retain radioactive potassium.

Salt After Adrenalectomy. IV. Urinary Nitrogen and Survival Time of the Fasted Adrenalectomized Salt-treated Rat.

Conclusion Fasted adrenalectomized rats treated with NaCl excrete nitrogen in amounts comparable with that of hormone-treated controls or that of normal animals, for at least 5 days of fasting. The survival time of such animals is also somewhat prolonged.

Salt after Adrenalectomy. III. Carbohydrate Stores in Adrenal-ectomized Rats Given Various Levels of Sodium Chloride.

Summary The adrenalectomized rat given 650-940 mg NaCl daily stores fed glucose as liver glycogen almost as well as does an intact animal. A NaCl intake of 1200 mg seems to interfere with glycogen storage in both adrenalectomized and intact animals.

Salt After Adrenalectomy. IL Urinary Excretion of Radioactive Na and K in Adrenalectomized Rats Given Various Levels of Salt.

Summary The administration of sodium chloride to adult adrenalectomized rats in amounts varying from 650 mg to 1 g daily prevents the urinary sodium wastage and potassium retention which characterizes adrenalectomized animals.