Vivekenanda Pateda

Hubungan Antara Acanthosis Nigricans dengan Riwayat Keluarga Diabetes Melitus Tipe 2 pada Anak-Anak Overweight dan Obes

Latar belakang. Angka kejadian diabetes mellitus tipe-2 (DMT2) pada anak di beberapa tahun terakhir ini semakin meningkat seiring dengan meningkatnya angka kejadian obesitas pada anak. Acanthosis nigricans (AN) diyakini merupakan prediktor yang baik untuk mengetahui adanya hiperinsulinemia, yang merupakan prekursor dari DMT2. Penelitian terdahulu menunjukkan prevalensi AN lebih tinggi pada anak-anak yang overweight, obes, dan mereka yang memiliki riwayat keluarga DMT2. Tujuan. Menilai hubungan AN dengan riwayat keluarga dengan DMT2 pada anak overweight dan obes. Metode. Penelitian cross sectional pada anak sekolah menengah pertama di kecamatan Wenang. Dilakukan pemeriksaan fisik terhadap AN dan pengisian kuesioner berisi riwayat keluarga dengan DM tipe 2 pada 102 pelajar yang overweight dan obes. Data kemudian dianalisis menggunakan uji X2. Hasil. Didapatkan AN lebih banyak dijumpai pada anak obes (69,2%) dibandingkan overweight (44%). Riwayat keluarga dengan DM tipe 2 ditemukan pada 30,6% anak obes dengan AN dan 31,8% pada anak dengan overweight. Secara statistik perbedaan kedua prevalens tersebut di atas tidak bermakna. Kesimpulan. Tidak terdapat hubungan yang signifikan antara acanthosis nigricans dengan riwayat keluarga diabetes melitus tipe 2 pada anak-anak overweight dan obes.

Profile of fasting blood glucose in obese children with insulin resistance

Results There were 54 obese children, mean age 12.2 (11.9 to 12.5) years. Thirty seven (68.5%) boys and 17 (31.5%) girls. With 34 children (63%) had insulin resistance: 23 (67.6%) male sex, and 11 (32.4%) girls, 18 (52.9%) no history of diabetes mellitus in families and 16 (47.1%) were found in the family history of diabetes mellitus. The average fasting blood glucose level on average obese children with insulin resistance is higher than obese children without insulin resistance at 5.08 (4.9 to 5.2) mmol / L compared with 4.79 (4.6 to 4, 9), (p <0.003) mmol / L. Fasting Blood Glucose Level in obese children with insulin resistance was significantly higher than obese children who did not have insulin resistance. Conclusion The data from this study showed that the level of fasting blood glucose in obese children who had insulin resistance is higher than obese children without insulin resistance.

Indonesia national registry of children with type 2 diabetes mellitus

Results There are 38 children with T2DM (16 boys, 22 girls). Twenty two children are diagnosed at >10 years old. Cases come spreadly from 11 provinces, the most cases are from Jakarta (16), Central Java (7) and West Java (6). Most frequent cases are diagnosed in May, June and December. Almost all cases are diagnosed by Pediatric Endocrinologist (10 cases). Twenty children are obese. Only 10 children had weight loss and 1 child had ketoasidosis. Mean BMI at diagnosis is 24 (+2.2) kg/m2. Mean of A1c at diagnosis is 11.5% (+ 1.9). Therapy at diagnosis are oral hypoglycemic only (4), insulin only (11), combination of insulin and oral hypoglycemic (1). Diabetes family histories are found in 16 subjects, (1 T1DM and 15 T2DM); 4 subjects have no family history.

Correlation between acanthosis nigricans and insulin resistance in obese children in Manado

Methods We performed a cross sectional analytic observational study. One hundred twenty three obese children, ages 10 – 14 years with and without acanthosis nigricans got examined for insulin resistance using Homeostasis Model Assessment of Insulin Resistance Index (HOMA-IR). Diagnosis of acanthosis nigricans is confirmed by a dermatologist. This study took place in Wenang district, Manado, North Sulawesi from October 2009 until January 2010.

The incidence of cryptorchidism among boys in some provinces in Indonesia

Background Cryptorchidism is a condition in which one or both testes are not fully descended to the bottom of the scrotum. It may be an important cause for male infertility. Numerous epidemiological studies indicate that the incidence has increased in many countries. The data about its incidence in Indonesia is still incomplete. Aims