W.J.B.M. van de Staak

Lichenoid Eruption Following Penicillamine

The phenomenon of lichenoid eruptions following medication with anti-malarial, anti-arthritis and antibacterial medication is well documented in the literature. We report here the first case to be des

Hyperkeratosis lenticularis perstans (Flegel)

2 patients with typical clinical and histological pictures of hyperkeratosis lenticularis perstans were described. Both patients showed abnormalities of the mucosal surface. The ultrastructural findings, both in the cutaneous and in the mucosal lesions, provide strong evidence that the mucosal abnormalities are a real component of hyperkeratosis lenticularis perstans.

Evaluation of the Frequency of Contact Allergic Reactions to Kathon CG in the Maastricht Area – 1987–1990

In the period 1987-1990, 999 patients suspected of a contact allergy were patch-tested with Kathon CG 100 ppm active ingredients aq. Of these patients, 84 (8.4%) showed a positive reaction (70% females). In 62% of these cases clinical relevance was established. Most of them suffered from contact dermatitis of the face, the hands or the perianal region.

Ultrastructural Abnormalities in the Skin Nerves of a Patient with Scleredema adultorum (Buschke) and Diabetes mellitus

In an electron-microscopic study of the skin of a patient with scleredema adultorum (Buschke) and diabetes mellitus, the unmyelinated nerve fibres showed accumulations of glycogen. On morphological grounds, these accumulations appeared to be located in the axons.

Intranuclear Particles in Keratoacanthoma: Possible Association with Malignant Degeneration

Electron microscopic investigation of 12 patients with keratoacanthoma is reported. Intranuclear virus-like particles, as described by Zelickson and Lynch, were seen in 3 cases; 2 of these subsequently underwent malignant degeneration. These findings suggest that it is particularly important to exclude the possibility of malignant change in those tumours when intranuclear particles are found.

Some Electron-Microscopic Aspects of Pemphigus erythematosus compared to those of Pemphigus vulgaris

1. The degree of disappearance of the desmosomes in established pemphigus erythematosus blister resembles that in an early blister in pemphigus vulgaris. One might consider pemphigus erythematosus as a pemphigus vulgaris which has remained in its initial phase. 2. The degree of disappearance of desmosomes in pemphigus erythematosus appears to be less than in pemphigus foliaceus.