Weimin Guo
Tufts University
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Publication
Featured researches published by Weimin Guo.
The FASEB Journal | 2006
Carla Marques; Weimin Guo; Paulo Pereira; Allen Taylor; Cam Patterson; Paul C. Evans; Fu Shang
Accumulation of damaged proteins is causally related to many age‐related diseases. The ubiquitin‐proteasome pathway (UPP) plays a role in selective degradation of damaged proteins, whereas molecular chaperones, such as heat shock proteins, are involved in refolding denatured proteins. This work demonstrates for the first time that the UPP and molecular chaperones work in a competitive manner and that the fates of denatured proteins are determined by the relative activities of the UPP and molecular chaperones. Enhanced UPP activity suppresses the refolding of denatured proteins whereas elevated chaperone activity inhibits the degradation of denatured proteins. CHIP, a co‐chaperone with E3 activity, plays a pivotal role in determining the fates of the damaged proteins. The delicate balance between UPP‐mediated degradation and refolding of denatured proteins is governed by relative levels of CHIP and other molecular chaperones. Isopeptidases, the enzymes that reverse the actions of CHIP, also play an important role in determining the fate of denatured proteins.
Journal of Biological Chemistry | 2005
Fu Shang; Gejing Deng; Qing Liu; Weimin Guo; Arthur L. Haas; Bernat Crosas; Daniel Finley; Allen Taylor
Investigative Ophthalmology & Visual Science | 2004
Weimin Guo; Fu Shang; Qing Liu; Lyudmila Urim; Judith A. West-Mays; Allen Taylor
Experimental Eye Research | 2006
Alexandre F. Fernandes; Weimin Guo; Xinyu Zhang; Matthew Gallagher; Mircea Ivan; Allen Taylor; Paulo Pereira; Fu Shang
Experimental Eye Research | 2004
Qing Liu; Fu Shang; Weimin Guo; Marisa Hobbs; Paloma Valverde; Venkat N. Reddy; Allen Taylor
Investigative Ophthalmology & Visual Science | 2006
Weimin Guo; Fu Shang; Qing Liu; Lyudmila Urim; Minlei Zhang; Allen Taylor
Investigative Ophthalmology & Visual Science | 2006
Qing Liu; Fu Shang; Elizabeth A. Whitcomb; Weimin Guo; Wei Li; Allen Taylor
The FASEB Journal | 2010
Fu Shang; Weimin Guo; Allen Taylor; Qingning Bian
The FASEB Journal | 2006
Fu Shang; Weimin Guo; Carla Marques; Allen Taylor; Paulo Pereira
Investigative Ophthalmology & Visual Science | 2005
Fu Shang; Weimin Guo; Carla Marques; Allen Taylor; Paulo Pereira