Wenge Cui
Albany Molecular Research, Inc.
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Publication
Featured researches published by Wenge Cui.
ACS Medicinal Chemistry Letters | 2014
Shuang Liu; Congxiang Zha; Kassoum Nacro; Min Hu; Wenge Cui; Yuh-Lin Yang; Ulhas Bhatt; Aruna Sambandam; Matthew Isherwood; Larry Yet; Michael Herr; Sarah M. Ebeltoft; Carla Hassler; Linda Fleming; Anthony D. Pechulis; Anne Payen-Fornicola; Nicholas Holman; Dennis Milanowski; Ian C. Cotterill; Vadim V. Mozhaev; Yuri L. Khmelnitsky; Peter R. Guzzo; Bruce J. Sargent; Bruce F. Molino; Richard E. Olson; Dalton King; Snjezana Lelas; Yu-Wen Li; Kim A. Johnson; Thaddeus F. Molski
A series of 4-bicyclic heteroaryl 1,2,3,4-tetrahydroisoquinoline inhibitors of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) was discovered. The synthesis and structure-activity relationship (SAR) of these triple reuptake inhibitors (TRIs) will be discussed. Compound 10i (AMR-2), a very potent inhibitor of SERT, NET, and DAT, showed efficacy in the rat forced-swim and mouse tail suspension models with minimum effective doses of 0.3 and 1 mg/kg (po), respectively. At efficacious doses in these assays, 10i exhibited substantial occupancy levels at the three transporters in both rat and mouse brain. The study of the metabolism of 10i revealed the formation of a significant active metabolite, compound 13.
Archive | 2008
Bruce F. Molino; Shuang Liu; Aruna Sambandam; Peter R. Guzzo; Min Hu; Congxiang Zha; Kassoum Nacro; David D. Manning; Matthew Isherwood; Kristen N. Fleming; Wenge Cui; Richard E. Olson
Archive | 2009
Paul Lobben; Rulin Zhao; Bei Wang; Bang-Chi Chen; Shuang Liu; Min Hu; Yuh-Lin Allen Yang; Matthew Isherwood; Rasidul Amin; Wenge Cui
Archive | 2009
Paul Lobben; Rulin Zhao; Bei Wang; Bang-Chi Chen; Shuang Liu; Min Hu; Yuh-Lin Allen Yang; Matthew Isherwood; Rasidul Amin; Wenge Cui
Tetrahedron-asymmetry | 2017
Jianqing Li; Daniel Smith; Subramaniam Krishnananthan; Dauh-Rurng Wu; Dawn Sun; Peng Li; Kristen N. Ryan; Min Hu; Wenge Cui; Jennifer Naginskaya; Shuang Liu; Paul C. Lobben; Alicia T. Ng; Richard E. Olson; Arvind Mathur
Organic Process Research & Development | 2016
Paul C. Lobben; Rasidul Amin; Bang-Chi Chen; Wenge Cui; Min Hu; Matthew Isherwood; Shuang Liu; Kassoum Nacro; Brandon Miles; Bingidimi I. Mobele; Richard E. Olson; Bei Wang; Yuh-Lin Yang; Rulin Zhao
Archive | 2009
Paul C. Lobben; Rulin Zhao; Bei Wang; Bang-Chi Chen; Shuang Liu; Min Hu; Yuh-Lin Allen Yang; Matthew Isherwood; Rasidul Amin; Wenge Cui
Archive | 2009
Paul C. Lobben; Rulin Zhao; Bei Wang; Bang-Chi Chen; Shuang Liu; Min Hu; Yuh-Lin Allen Yang; Matthew Isherwood; Rasidul Amin; Wenge Cui
Archive | 2008
Peter R. Guzzo; Bruce F. Molino; Wenge Cui; Shuang Liu; Richard E. Olson
Archive | 2008
Peter R. Guzzo; Bruce F. Molino; Wenge Cui; Shuang Liu; Richard E. Olson
