Paul C. Lobben | Researchain

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Featured researches published by Paul C. Lobben.

Organic Letters | 2018

Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes

Gregory L. Beutner; Ronald Carrasquillo; Peng Geng; Yi Hsiao; Eric C. Huang; Jacob Janey; Kishta Katipally; Sergei V. Kolotuchin; Thomas La Porte; Andrew Lee; Paul C. Lobben; Federico Lora-Gonzalez; Brendan Mack; Boguslaw Mudryk; Yuping Qiu; Xinhua Qian; Antonio Ramirez; Thomas M. Razler; Thorsten Rosner; Zhongping Shi; Eric M. Simmons; Jason Stevens; Jianji Wang; Carolyn S. Wei; Steven R. Wisniewski; Ye Zhu

A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.

Organic Process Research & Development | 2014

Commercial Synthesis of a Pyrrolotriazine–Fluoroindole Intermediate to Brivanib Alaninate: Process Development Directed toward Impurity Control

Jaan A. Pesti; Thomas L. LaPorte; John E. Thornton; Lori Spangler; Frederic G. Buono; Gerard Crispino; Frank Gibson; Paul C. Lobben; Christos G. Papaioannou

Organic Process Research & Development | 2012

Development of a Practical Synthesis of a p38 Kinase Inhibitor via a Safe and Robust Amination

Zhongping Shi; Susanne Kiau; Paul C. Lobben; John Hynes; Hong Wu; Luca Parlanti; Robert P. Discordia; Wendel W. Doubleday; Katerina Leftheris; Alaric J. Dyckman; Stephen T. Wrobleski; Konstantinos Dambalas; Srinivas Tummala; Simon Leung; Ehrlic Lo

Organic Process Research & Development | 2004

Integrated Approach to the Development and Understanding of the Borane Reduction of a Carboxylic Acid

Paul C. Lobben; Simon Shun-Wang Leung; Srinivas Tummala

Organic Process Research & Development | 2014

Development of a Continuous Plug Flow Process for Preparation of a Key Intermediate for Brivanib Alaninate

Thomas L. LaPorte; Lori Spangler; Mourad Hamedi; Paul C. Lobben; Steven H. Chan; Jale Muslehiddinoglu; Steve Wang

Archive | 2005

Methods for the preparation of pyrrolotriazine compounds

Paul C. Lobben

Organic Process Research & Development | 2014

A Method for Heteroaromatic Nitration Demonstrating Remarkable Thermal Stability

Gregory L. Beutner; Lopa V. Desai; Dayne Fanfair; Paul C. Lobben; Eric Anderson; Simon Leung; Martin D. Eastgate

Organic Process Research & Development | 2015

Control Strategy for the Manufacture of Brivanib Alaninate, a Novel Pyrrolotriazine VEGFR/FGFR Inhibitor

Paul C. Lobben; Evan T. Barlow; James S. Bergum; Alan D. Braem; Shih-Ying Chang; Frank Gibson; Nathaniel Kopp; Chiajen Lai; Thomas L. LaPorte; David K. Leahy; Jale Muslehiddinoglu; Fernando Quiroz; Dimitri Skliar; Lori Spangler; Sushil Srivastava; Daniel Wasser; John Wasylyk; Robert Wethman; Zhongmin Xu

Archive | 2007

Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2, 1-F][1,2,4]triazin-6-yloxy]-1-methylethyl ester

Gerard Crispino; Mourad Hamedi; Thomas L. LaPorte; John E. Thornton; Jaan A. Pesti; Zhongmin Xu; Paul C. Lobben; David K. Leahy; Jale Muslehiddinoglu; Chiajen Lai; Lori Spangler; Robert P. Discordia

Catalysis Today | 2007