Wietske Andrea Christoffers

Drug survival for ciclosporin A in a long-term daily practice cohort of adult patients with atopic dermatitis

Long‐term data of ciclosporin A (CsA) treatment in daily practice in patients with severe atopic dermatitis (AD) are lacking.

Two decades of occupational (meth)acrylate patch test results and focus on isobornyl acrylate

Acrylates constitute an important cause of occupational contact dermatitis. Isobornyl acrylate sensitization has been reported in only 2 cases. We encountered an industrial process operator with occupational contact dermatitis caused by isobornyl acrylate.

Patch test results of hand eczema patients: relation to clinical types

Allergic contact dermatitis is a well‐known cause of hand eczema, although the influence of contact allergens on different clinical types of hand eczema remains still unclear.

The optimal patch test concentration for ascaridole as a sensitizing component of tea tree oil.

Tea tree oil is used as a natural remedy, but is also a popular ingredient in household and cosmetic products. Oxidation of tea tree oil results in degradation products, such as ascaridole, which may cause allergic contact dermatitis.

Severe bullous allergic contact dermatitis caused by glycidyl methacrylate and other acrylates

Keywords: acrylate; allergic contact dermatitis; bullous contact allergy; occupational; 1,6-hexanediol diacrylate, glycidyl methacrylate.

Bullous allergic reaction caused by colophonium in medical adhesives

Colophonium (rosin, CAS no. 8050-09-7) is a complex mixture of > 100 different compounds derived from pine trees. It is a good tackifier, can be used as an emulsifier, and has acid properties without causing corrosion. Because of these properties, colophonium is used in various products, such as soldering fluxes, paper, cosmetics (depilatory waxes, soaps, hair gel, and nail polish), cutting fluids, insulation materials, and adhesives such as medical adhesives.

Co-sensitization to ascaridole and tea tree oil

Tea tree oil (Melaleuca alternifolia, CAS no. 68647-73-4) is an oil distilled from the leaves of M. alternifolia. Indigenous populations in Australia used it as an antiseptic and as an alternative herbal medicine for centuries, but tea tree oil is now an increasingly popular ingredient in household and cosmetic products. Various reports of contact allergy to tea tree oil exist; however, the sensitizing component is still an issue of debate.

Drug survival of cyclosporine in the treatment of hand eczema: a multicentre, daily use study

Hand eczema is a common condition; it is often chronic and can be difficult to treat. Cyclosporine is used off‐label to treat severe hand eczema; however, the evidence for this treatment is scarce.

Drug survival of methotrexate treatment in hand eczema patients: results from a retrospective daily practice study

for the negative result of CEA in the Bowenoid lesions (Fig. 2b). Therefore, to confirm the cell lineage of Bowenoid cells, Ber-EP4 and CK5/6 staining were added. EMPD has been reported to stain positive with Ber-EP4, whereas Bowen’s disease stains negative. CK5/6 are positive in Bowen’s disease, but negative in EMPD. The Bowenoid cells in our case demonstrated the characteristic immunohistochemical features of Paget cells (Fig. 2c, d). These results indicate that the Bowenoid cells in our case were not derived from keratinocytes. In summary, our detailed pathological examination, in addition to the literature review, has clarified the immunohistochemical profiles of EMPD with Bowenoid features. We propose that Ber-EP4 and CK5/6 staining can improve the diagnostic accuracy when the clinician suspects atypical cases of Bowenoid EMPD.

Atypical presentation of painful vesicles on the hands and feet in an immunocompromised adult

A 41-year-old Caucasian male presented at the Department of ermatology with a two day history of a painful papulovesicular ruption on the hands and feet (Fig. 1). The lesions started on the almar site of the hands after the patient suffered from fever, genral malaise, and a mild cough. Subsequently, the lesions appeared n the dorsal site of hands and fingers and on the feet as well, xtending to the calves within 48 h. The symptoms started several ours after visiting a public swimming pool. The patient had not een exposed to animals and had not travelled to foreign countries, xcept for Denmark, in the previous weeks. Several days before the tart of the eruption, his six-year-old daughter had been ill and his ife had suffered from herpes labialis. However, the patient had ever had clinical signs of herpes and moreover denied to suffer rom any oral lesions or symptoms. The patient had a history of Wegener’s granulomatosis, diagosed in 1997, for which he was first treated with steroids, yclophosphamide and mycofenolate mofetil (Cellcept®). In 2011 e experienced his last relapse, and eversince used azathiorine 150 mg daily, without signs of a reactivation. Furthermore, e used omeprazole and co-trimoxazole for years and started ydrochlorothiazide three weeks earlier because of hypertension. n addition he suffered from psoriasis vulgaris for years, treated ith topical calcipotriol/betamethasone dipropionate. Dermatological examination on day three of the eruption evealed livid-erythematous, mainly dried up lenticular (papulo) esicles on the palmar and dorsal site of hands and wrists. His feet ere affected with similar lesions and interdigital bullae and ero-