William Antopol

Variations in birth cries of newborn infants from narcotic-addicted and normal mothers

Abstract Sound spectrographs were performed on the birth cries of 369 neonates. Thirty-one were neonates born to drug-addicted mothers. A schema for the classifications of infant vocalization differentiating normal and abnormal spectrograms is presented. There was a significant statistical increase in abnormal voice spectrogram to babies born of addicted mothers.

Retardation of Growth of Implants of Carcinoma 755 in Cortisone-Injected Mice

Summary 1. Cortisone, when administered during the first few days after transplantation of carcinoma 755 in C57 mice, has a profound inhibitory effect on growth of the tumor but the tumor remains viable. 2. These effects of cortisone appear to be due to the change in the environment and to the delay in new blood vessel formation about the tumor transplant.

Gholine Esterase Activity in Various Portions of the Rabbit Heart

Summary 1. The choline esterase concentration in the auricles of the rabbit heart was found to be considerably greater than that in the ventricles. 2. These data may be interpreted as supporting the viewpoint that there is an enzyme protective mechanism operating in the vagus system.

Potentiation of the local Shwartzman phenomenon by trypsin.

Summary 1) Trypsin potentiates the effect of skin preparatory substances in elicitation of the Shwartzman Phenomenon. 2) In combination with trypsin, the skin reacts to a greater degree and with lower concentrations of the preparatory factor.

COMPARISON OF ENZYME ACTIVITY IN MALIGNANT AND ADJACENT UNINVOLVED TISSUE.

Summary Homogenates of the neoplastic and adjacent non-malignant tissues from patients with adenocarcinoma of the colon were prepared and assayed spectrophotometrically for LD, MD, and enolase. Significant differences in enzyme activity were observed between the tumor homogenates and the homogenates of the uninvolved tissue. The activities of LD, MD, and enolase were significantly higher in the tumor preparations than in the preparations of adjacent mucosal tissue. These results are consistent with the hypothesis that the tumor proper is one of the sources of the elevated serum levels of the 3 enzymes.

Influence of tetrazolium salts on human pseudocholinesterase.

Summary Neurotoxic effects of tetrazolium salts may be due to interference with enzyme systems in nerve tissue. Six tetrazolium salts were found to inhibit pseudocholinesterase, with the ditetrazoliums generally exhibiting more marked inhibitory activity than the monotetrazoliums. This may be related to the greater number of tertiary amine groups in the ditetrazoliums.