William Boffey Jamieson

The comparative in vitro pharmacology of leukotriene D4 and its isomers

Abstract The 5R,6S and 5S,6R isomers of leukotriene D4 (LTD4), 9cis LTD4, 9cis,11trans LTD4 and 11trans LTD4 were synthesized for comparative pharmacological studies on intestinal and respiratory smooth muscle preparations. The 5S,6R isomers are biologically active, modification of the double bond stereochemistry causing only a moderate reduction in activity. The 5R,6S isomers possess approximately 1% the biological activity of their respective 5S,6R forms.

Synthesis, separation and N.M.R. spectra of three double bond isomers of leukotriene a methyl ester

Abstract The synthesis and h.p.l.c. separation of three double bond isomers of leukotriene A methyl ester is described, their stereochemistry being assigned by 1 H N.M.R.

Antiparasitic nitroimidazoles. 8. Derivatives of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole.

A series of 33 thioacetals and hydrazones of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole was prepared and examined for antitrypanosomal properties. The thioacetals were inactive as antitrypanosomal agents but three hydrazones derived from N-aminoguanidine, pyridylacethohydrazide chloride (Girard reagent P), and dimethylaminoacetohydrazide (Girard reagent D) displayed good activity against Trypanosoma rhodesiense.

Synthesis of the 9Z and 9Z, 11E isomers of leukotriene C4

Abstract Synthesis of the 9Z and 9Z, 11E isomers of leukotriene C 4 is described, the stereochemistry of the former was confirmed by its facile 1,7 hydride shift reaction.