William James Ross

The synthesis and rearrangement of epoxypyrones

Abstract The oxidation of 5-acyl-4-oxo-pyran-2-carboxylic acid esters 1 , 2 to novel epoxypyrones and subsequent rearrangement to the previously inaccessible 6-substituted-5-hydroxy or 5-chloropyrones 6 - 9 are described.

Synthesis of 8,9-leukotriene C3 and D3

Abstract An asymmetric epoxidation provides a short convenient synthesis of 8,9-leukotrienes C 3 and D 3 .

Synthesis, separation and N.M.R. spectra of three double bond isomers of leukotriene a methyl ester

Abstract The synthesis and h.p.l.c. separation of three double bond isomers of leukotriene A methyl ester is described, their stereochemistry being assigned by 1 H N.M.R.

First alkylation of a 1-methoxy-substituted tricarbonyl(η5-cyclohexadienyl)iron(1 +) complex

Abstract A 1,2-dimethoxy-substituted tricarbonyl(η 5 -cyclohexadienyl(iron(1 +) cation was alkylated predominantly at C(1) to afford an adduct which was converted into a 1-carbomethoxymethyl-2-methoxy-substituted dienyl complex in the first regiocontrolled reaction sequence involving a 1-methoxydienyl complex as a synthetic intermediate.

Antiparasitic nitroimidazoles. 8. Derivatives of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole.

A series of 33 thioacetals and hydrazones of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole was prepared and examined for antitrypanosomal properties. The thioacetals were inactive as antitrypanosomal agents but three hydrazones derived from N-aminoguanidine, pyridylacethohydrazide chloride (Girard reagent P), and dimethylaminoacetohydrazide (Girard reagent D) displayed good activity against Trypanosoma rhodesiense.

Synthesis of the 9Z and 9Z, 11E isomers of leukotriene C4

Abstract Synthesis of the 9Z and 9Z, 11E isomers of leukotriene C 4 is described, the stereochemistry of the former was confirmed by its facile 1,7 hydride shift reaction.