William C. Thomas

UNILATERAL RENAL DISEASE AS A CAUSE OF HYPERTENSION: ITS DETECTION BY URETERAL CATHETERIZATION STUDIES

Excerpt It has been amply demonstrated experimentally that renal ischemia can result in hypertension1-3and that, in man, reduced arterial flow toonekidney may produce a clinical picture indistingui...

Hypercalcemic Crisis Due to Hyperparathyroidism

Abstract A potentially fatal course characterized by rapidly progressive nausea, vomiting, lethargy and azotemia is occasionally encountered in patients with hyperparathyroidism. Three such patients having these manifestations are reported. In two, recognition was sufficiently prompt, and an emergency removal of a parathyroid adenoma resulted in a successful outcome in each. In the third patient the correct diagnosis was suspected only two hours before death. Similar clinical manifestations occur with marked hypercalcemia of any etiology. Although the pathogenesis of this syndrome is not clearly understood, successful treatment seems dependent on prompt reduction of the high serum calcium concentrations.

Diagnostic considerations in hypercalcemia; with a discussion of the various means by which such a state may develop.

DESPITE knowledge that hypercalcemia, regardless of cause, is injurious and potentially lethal, there is wide variation in the diligence with which its presence or absence is determined in patients...

Extracorporeal shock-wave lithotripsy.

Excerpt Extracorporeal shock-wave lithotripsy is a technique for pulverizing urinary stones in vivo by focusing hydraulic shock waves on the stone (1-3). This innovative form of therapy is the by-p...

Parathyroid adenomas in chronic rickets

Hyperplasia and hyperfunction of the parathyroid glands has been well documented in experimental and clinical rickets. Resistant rickets is characteristically of long duration, but there has been only one previously reported instance of hyperparathyroidism developing in this disorder. A second instance of the occurrence of multiple parathyroid tumors in a patient with congenital resistant rickets is reported herein. The increasingly frequent recognition of hyperparathyroidism developing in patients with various chronic disorders in which there has been concurrent hyperfunction of the parathyroid glands (malabsorption states, renal disease with azotemia and rickets) provides convincing evidence that persistent hyperfunction of these glands increases susceptibility to adenoma formation.

Urinary Tract Calculi

Excerpt An international symposium on research in renal stone formation was held in Leeds, England, on April 17 to 20, 1968. Investigators from 8 countries presented 34 papers, each of which was fo...