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Dive into the research topics where William Dennis Kingsbury is active.

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Featured researches published by William Dennis Kingsbury.


Bioorganic & Medicinal Chemistry Letters | 1997

Quinine analogs as non-peptide calcitonin gene-related peptide (CGRP) receptor antagonists

Robert A. Daines; Kelvin Sham; Jack J. Taggart; William Dennis Kingsbury; James Chan; Ann L. Breen; Jyoti Disa; Nambi Aiyar

Abstract A high-throughput screen identified quinine analog 1 as an antagonist of the human calcitonin generelated peptide (hCGRP) receptor. Thus, compound 1 displaces [125I]-CGRP from the hCGRP receptor and inhibits CGRP-mediated cAMP production with IC50 values of 5.9 ± 1.2 μM and 26 ± 5 μM, respectively. A limited structure-activity study of 1 is described.


Journal of The Chemical Society D: Chemical Communications | 1969

Oxidation of sulphides to sulphoxides with 1-chlorobenzotriazole

William Dennis Kingsbury; Carl R. Johnson

Sulphides are quickly and efficiently converted into sulphoxides, without concomitant formation of sulphones, by 1-chlorobenzotriazole.


Archive | 1988

Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells

Jeffrey Charles Boehm; Sidney Michael Hecht; Kenneth G. Holden; Randall K. Johnson; William Dennis Kingsbury


Journal of Organic Chemistry | 1994

Synthesis and anti-HSV activity of A-ring-deleted mappicine ketone analog

Israil Pendrak; Shawn O'Lin Barney; Robert Wittrock; Dennis M. Lambert; William Dennis Kingsbury


Journal of Organic Chemistry | 1995

Synthesis and Anti-HSV Activity of Methylenedioxy Mappicine Ketone Analogs

Israil Pendrak; Robert Wittrock; William Dennis Kingsbury


Journal of Organic Chemistry | 1986

Rapid and convenient syntheses of polyoxin peptides containing N-methylated peptide bonds

Jeffrey Charles Boehm; William Dennis Kingsbury


Journal of Medicinal Chemistry | 1993

Synthesis and LTB4 receptor antagonist activities of the naturally occurring LTB4 receptor antagonist leucettamine A and related analogues

Jeffrey Charles Boehm; John G. Gleason; Israil Pendrak; Henry M. Sarau; Dulcie B. Schmidt; James J. Foley; William Dennis Kingsbury


Archive | 2003

Imidazolium cxcr3 inhibitors

Jeffrey M. Axten; James J. Foley; William Dennis Kingsbury; Henry M. Sarau


Archive | 1991

Substituted indolizino[1,2-b]quinolinones

David Alan Berges; Robert P. Hertzberg; Randall K. Johnson; William Dennis Kingsbury


Archive | 1992

Pyridine compounds for treating leukotriene-related diseases

Pamela A. Chambers; Robert A. Daines; Dalia R. Jakas; William Dennis Kingsbury; Israil Pendrak

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