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Featured researches published by William E. Biddison.


Immunological Reviews | 1989

CD4 Expression and Function in HLA Class Il‐Specific T Cells

William E. Biddison; Stephen Shaw

The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. Our studies of CD4 expression and function on class II-specific T cells indicate that: 1) CD4 expression is generally a marker of T cells that are committed to class II antigen recognition, even when they have cytotoxic function; 2) CD4 is typically involved in the proliferative and cytotoxic function of such cells, which we hypothesized to be due to interaction with a nonpolymorphic determinant on class II; 3) the importance of CD4 to the recognition is most prominent in T-cell interactions with low avidity; and 4) although CD4 may play a role in adhesion per se, the majority of its function seems to be in a post-adhesion phase of cytotoxic T-cell recognition.


Journal of Experimental Medicine | 1984

Possible involvement of the T4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of CTL-target cell binding.

William E. Biddison; Patricia E. Rao; Mary Anne Talle; Gideon Goldstein; Stephen Shaw


Journal of Experimental Medicine | 1978

Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype

Peter C. Doherty; William E. Biddison; Jack R. Bennink; Barbara B. Knowles


Journal of Experimental Medicine | 1977

Antibody to influenza virus matrix protein detects a common antigen on the surface of cells infected with type A influenza viruses.

William E. Biddison; Peter C. Doherty; Robert G. Webster


Biochemistry | 2003

Thermodynamic and Kinetic Analysis of a Peptide−Class I MHC Interaction Highlights the Noncovalent Nature and Conformational Dynamics of the Class I Heterotrimer†

Anne-Kathrin Binz; Rene C. Rodriguez; William E. Biddison; Brian M. Baker


Journal of Biological Chemistry | 2004

Strategic Mutations in the Class I Major Histocompatibility Complex HLA-A2 Independently Affect Both Peptide Binding and T Cell Receptor Recognition

Tiffany K. Baxter; Susan J. Gagnon; Rebecca L. Davis-Harrison; J. C. Beck; Anne-Kathrin Binz; Richard V. Turner; William E. Biddison; Brian M. Baker


Journal of Experimental Medicine | 1978

Involvement of H-2L gene products in virus-immune T-cell recognition. Evidence for an H-2L-restricted T-cell response.

William E. Biddison; Ted H. Hansen; Robert B. Levy; Peter C. Doherty


Journal of Experimental Medicine | 1977

Induction of virus-specific modifications recognized by cytotoxic T cells is not altered by prior substitution of target cells with trinitrophenol.

William E. Biddison; H R Snodgrass; Jack R. Bennink; Rita B. Effros; Peter C. Doherty


Journal of Immunology | 2010

Pillars Article: Structure of the Complex Between Human T-Cell Receptor, Viral Peptide and HLA-A2. Nature. 1996. 384: 134–141

David N. Garboczi; Partho Ghosh; Ursula Utz; Qing R. Fan; William E. Biddison; Don C. Wiley


Archive | 1999

Four A6-TCR / peptide / HLA-A2 structures that Alam

Yan Ding; Brian M. Baker; David N. Garboczi; William E. Biddison; Don C. Wiley

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David N. Garboczi

National Institutes of Health

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Don C. Wiley

Howard Hughes Medical Institute

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Brian M. Baker

University of Notre Dame

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Brian M. Baker

University of Notre Dame

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Gideon Goldstein

Memorial Sloan Kettering Cancer Center

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Mary Anne Talle

National Institutes of Health

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Partho Ghosh

University of California

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Patricia E. Rao

National Institutes of Health

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