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Dive into the research topics where William M. McMahon is active.

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Featured researches published by William M. McMahon.


Nature | 2009

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

Joseph T. Glessner; Kai Wang; Guiqing Cai; Olena Korvatska; Cecilia E. Kim; Shawn Wood; Haitao Zhang; Annette Estes; Camille W. Brune; Jonathan P. Bradfield; Marcin Imielinski; Edward C. Frackelton; Jennifer Reichert; Emily L. Crawford; Jeffrey Munson; Patrick Sleiman; Rosetta M. Chiavacci; Kiran Annaiah; Kelly Thomas; Cuiping Hou; Wendy Glaberson; James H. Flory; Frederick G. Otieno; Maria Garris; Latha Soorya; Lambertus Klei; Joseph Piven; Kacie J. Meyer; Evdokia Anagnostou; Takeshi Sakurai

Autism spectrum disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies focusing on candidate genes or genomic regions have identified several copy number variations (CNVs) that are associated with an increased risk of ASDs. Here we present the results from a whole-genome CNV study on a cohort of 859 ASD cases and 1,409 healthy children of European ancestry who were genotyped with ∼550,000 single nucleotide polymorphism markers, in an attempt to comprehensively identify CNVs conferring susceptibility to ASDs. Positive findings were evaluated in an independent cohort of 1,336 ASD cases and 1,110 controls of European ancestry. Besides previously reported ASD candidate genes, such as NRXN1 (ref. 10) and CNTN4 (refs 11, 12), several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGN1 and ASTN2, were enriched with CNVs in ASD cases compared to controls (P = 9.5 × 10-3). Furthermore, CNVs within or surrounding genes involved in the ubiquitin pathways, including UBE3A, PARK2, RFWD2 and FBXO40, were affected by CNVs not observed in controls (P = 3.3 × 10-3). We also identified duplications 55 kilobases upstream of complementary DNA AK123120 (P = 3.6 × 10-6). Although these variants may be individually rare, they target genes involved in neuronal cell-adhesion or ubiquitin degradation, indicating that these two important gene networks expressed within the central nervous system may contribute to the genetic susceptibility of ASD.


Nature | 2009

Common genetic variants on 5p14.1 associate with autism spectrum disorders

Kai Wang; Haitao Zhang; Deqiong Ma; Maja Bucan; Joseph T. Glessner; Brett S. Abrahams; Daria Salyakina; Marcin Imielinski; Jonathan P. Bradfield; Patrick Sleiman; Cecilia E. Kim; Cuiping Hou; Edward C. Frackelton; Rosetta M. Chiavacci; Nagahide Takahashi; Takeshi Sakurai; Eric Rappaport; Clara M. Lajonchere; Jeffrey Munson; Annette Estes; Olena Korvatska; Joseph Piven; Lisa I. Sonnenblick; Ana I. Alvarez Retuerto; Edward I. Herman; Hongmei Dong; Ted Hutman; Marian Sigman; Sally Ozonoff; Ami Klin

Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental and neuropsychiatric disorders characterized by deficits in verbal communication, impairment of social interaction, and restricted and repetitive patterns of interests and behaviour. To identify common genetic risk factors underlying ASDs, here we present the results of genome-wide association studies on a cohort of 780 families (3,101 subjects) with affected children, and a second cohort of 1,204 affected subjects and 6,491 control subjects, all of whom were of European ancestry. Six single nucleotide polymorphisms between cadherin 10 (CDH10) and cadherin 9 (CDH9)—two genes encoding neuronal cell-adhesion molecules—revealed strong association signals, with the most significant SNP being rs4307059 (P = 3.4 × 10-8, odds ratio = 1.19). These signals were replicated in two independent cohorts, with combined P values ranging from 7.4 × 10-8 to 2.1 × 10-10. Our results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to our knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs.


American Journal of Human Genetics | 1999

A Genomic Screen of Autism: Evidence for a Multilocus Etiology

Neil Risch; Donna Spiker; Linda Lotspeich; Nassim Nouri; David A. Hinds; Joachim Hallmayer; Luba Kalaydjieva; Patty McCague; Sue Dimiceli; Tawna Pitts; Loan Nguyen; Joan Yang; Courtney Harper; Danielle Thorpe; Saritha Vermeer; Helena Young; Joan M. Hebert; Alice Lin; Joan Ferguson; Carla Chiotti; Susan Wiese‐Slater; Tamara Rogers; Boyd Salmon; Peter Nicholas; P. Brent Petersen; Carmen Pingree; William M. McMahon; Dona L. Wong; Luigi Luca Cavalli-Sforza; Helena C. Kraemer

We have conducted a genome screen of autism, by linkage analysis in an initial set of 90 multiplex sibships, with parents, containing 97 independent affected sib pairs (ASPs), with follow-up in 49 additional multiplex sibships, containing 50 ASPs. In total, 519 markers were genotyped, including 362 for the initial screen, and an additional 157 were genotyped in the follow-up. As a control, we also included in the analysis unaffected sibs, which provided 51 discordant sib pairs (DSPs) for the initial screen and 29 for the follow-up. In the initial phase of the work, we observed increased identity by descent (IBD) in the ASPs (sharing of 51.6%) compared with the DSPs (sharing of 50.8%). The excess sharing in the ASPs could not be attributed to the effect of a small number of loci but, rather, was due to the modest increase in the entire distribution of IBD. These results are most compatible with a model specifying a large number of loci (perhaps >/=15) and are less compatible with models specifying </=10 loci. The largest LOD score obtained in the initial scan was for a marker on chromosome 1p; this region also showed positive sharing in the replication family set, giving a maximum multipoint LOD score of 2.15 for both sets combined. Thus, there may exist a gene of moderate effect in this region. We had only modestly positive or negative linkage evidence in candidate regions identified in other studies. Our results suggest that positional cloning of susceptibility loci by linkage analysis may be a formidable task and that other approaches may be necessary.


NeuroImage | 2007

Diffusion tensor imaging of the corpus callosum in Autism.

Andrew L. Alexander; Jee Eun Lee; Mariana Lazar; Rebecca Boudos; Molly B. DuBray; Terrence R. Oakes; Judith Miller; Jeffrey K. Lu; Eun Kee Jeong; William M. McMahon; Erin D. Bigler; Janet E. Lainhart

The corpus callosum is the largest commissural white matter pathway that connects the hemispheres of the human brain. In this study, diffusion tensor imaging (DTI) was performed on subject groups with high-functioning autism and controls matched for age, handedness, IQ, and head size. DTI and volumetric measurements of the total corpus callosum and subregions (genu, body and splenium) were made and compared between groups. The results showed that there were significant differences in volume, fractional anisotropy, mean diffusivity, and radial diffusivity between groups. These group differences appeared to be driven by a subgroup of the autism group that had small corpus callosum volumes, high mean diffusivity, low anisotropy, and increased radial diffusivity. This subgroup had significantly lower performance IQ measures than either the other individuals with autism or the control subjects. Measurements of radial diffusivity also appeared to be correlated with processing speed measured during the performance IQ tests. The subgroup of autism subjects with high mean diffusivity and low fractional anisotropy appeared to cluster with the highest radial diffusivities and slowest processing speeds. These results suggest that the microstructure of the corpus callosum is affected in autism, which may be related to nonverbal cognitive performance.


PLOS Genetics | 2009

Genome-Wide Analyses of Exonic Copy Number Variants in a Family-Based Study Point to Novel Autism Susceptibility Genes

Maja Bucan; Brett S. Abrahams; Kai Wang; Joseph T. Glessner; Edward I. Herman; Lisa I. Sonnenblick; Ana I. Alvarez Retuerto; Marcin Imielinski; Dexter Hadley; Jonathan P. Bradfield; Cecilia Kim; Nicole Gidaya; Ingrid Lindquist; Ted Hutman; Marian Sigman; Vlad Kustanovich; Clara M. Lajonchere; Andrew Singleton; Junhyong Kim; Thomas H. Wassink; William M. McMahon; Thomas Owley; John A. Sweeney; Hilary Coon; John I. Nurnberger; Mingyao Li; Rita M. Cantor; Nancy J. Minshew; James S. Sutcliffe; Edwin H. Cook

The genetics underlying the autism spectrum disorders (ASDs) is complex and remains poorly understood. Previous work has demonstrated an important role for structural variation in a subset of cases, but has lacked the resolution necessary to move beyond detection of large regions of potential interest to identification of individual genes. To pinpoint genes likely to contribute to ASD etiology, we performed high density genotyping in 912 multiplex families from the Autism Genetics Resource Exchange (AGRE) collection and contrasted results to those obtained for 1,488 healthy controls. Through prioritization of exonic deletions (eDels), exonic duplications (eDups), and whole gene duplication events (gDups), we identified more than 150 loci harboring rare variants in multiple unrelated probands, but no controls. Importantly, 27 of these were confirmed on examination of an independent replication cohort comprised of 859 cases and an additional 1,051 controls. Rare variants at known loci, including exonic deletions at NRXN1 and whole gene duplications encompassing UBE3A and several other genes in the 15q11–q13 region, were observed in the course of these analyses. Strong support was likewise observed for previously unreported genes such as BZRAP1, an adaptor molecule known to regulate synaptic transmission, with eDels or eDups observed in twelve unrelated cases but no controls (p = 2.3×10−5). Less is known about MDGA2, likewise observed to be case-specific (p = 1.3×10−4). But, it is notable that the encoded protein shows an unexpectedly high similarity to Contactin 4 (BLAST E-value = 3×10−39), which has also been linked to disease. That hundreds of distinct rare variants were each seen only once further highlights complexity in the ASDs and points to the continued need for larger cohorts.


Journal of the American Academy of Child and Adolescent Psychiatry | 2008

A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms

Katherine Gotham; Susan Risi; Geraldine Dawson; Helen Tager-Flusberg; Robert M. Joseph; Alice S. Carter; Susan Hepburn; William M. McMahon; Patricia M. Rodier; Susan L. Hyman; Marian Sigman; Sally J. Rogers; Rebecca Landa; M. Anne Spence; Kathryn Osann; Pamela Flodman; Fred R. Volkmar; Eric Hollander; Joseph D. Buxbaum; Andrew Pickles; Catherine Lord

OBJECTIVE To replicate the factor structure and predictive validity of revised Autism Diagnostic Observation Schedule algorithms in an independent dataset (N = 1,282). METHOD Algorithm revisions were replicated using data from children ages 18 months to 16 years collected at 11 North American sites participating in the Collaborative Programs for Excellence in Autism and the Studies to Advance Autism Research and Treatment. RESULTS Sensitivities and specificities approximated or exceeded those of the old algorithms except for young children with phrase speech and a clinical diagnosis of pervasive developmental disorders not otherwise specified. CONCLUSIONS Revised algorithms increase comparability between modules and improve the predictive validity of the Autism Diagnostic Observation Schedule for autism cases compared to the original algorithms.


American Journal of Medical Genetics Part A | 2006

Head circumference and height in autism : A study by the collaborative program of excellence in autism

Janet E. Lainhart; Erin D. Bigler; Maureen Bocian; Hilary Coon; Elena Dinh; Geraldine Dawson; Curtis K. Deutsch; Michelle Dunn; Annette Estes; Helen Tager-Flusberg; Susan E. Folstein; Susan Hepburn; Susan L. Hyman; William M. McMahon; Nancy J. Minshew; Jeff Munson; Kathy Osann; Sally Ozonoff; Patricia M. Rodier; Sally J. Rogers; Marian Sigman; M. Anne Spence; Christopher J. Stodgell; Fred R. Volkmar

Data from 10 sites of the NICHD/NIDCD Collaborative Programs of Excellence in Autism were combined to study the distribution of head circumference and relationship to demographic and clinical variables. Three hundred thirty‐eight probands with autism‐spectrum disorder (ASD) including 208 probands with autism were studied along with 147 parents, 149 siblings, and typically developing controls. ASDs were diagnosed, and head circumference and clinical variables measured in a standardized manner across all sites. All subjects with autism met ADI‐R, ADOS‐G, DSM‐IV, and ICD‐10 criteria. The results show the distribution of standardized head circumference in autism is normal in shape, and the mean, variance, and rate of macrocephaly but not microcephaly are increased. Head circumference tends to be large relative to height in autism. No site, gender, age, SES, verbal, or non‐verbal IQ effects were present in the autism sample. In addition to autism itself, standardized height and average parental head circumference were the most important factors predicting head circumference in individuals with autism. Mean standardized head circumference and rates of macrocephaly were similar in probands with autism and their parents. Increased head circumference was associated with a higher (more severe) ADI‐R social algorithm score. Macrocephaly is associated with delayed onset of language. Although mean head circumference and rates of macrocephaly are increased in autism, a high degree of variability is present, underscoring the complex clinical heterogeneity of the disorder. The wide distribution of head circumference in autism has major implications for genetic, neuroimaging, and other neurobiological research.


PLOS Genetics | 2008

A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction

Robert B. Weiss; Timothy B. Baker; Dale S. Cannon; Andrew von Niederhausern; Diane M. Dunn; Nori Matsunami; Nanda A. Singh; Lisa Baird; Hilary Coon; William M. McMahon; Megan E. Piper; Michael C. Fiore; Mary Beth Scholand; John E. Connett; Richard E. Kanner; Lorise C. Gahring; Scott W. Rogers; John R. Hoidal; M. Leppert

People who begin daily smoking at an early age are at greater risk of long-term nicotine addiction. We tested the hypothesis that associations between nicotinic acetylcholine receptor (nAChR) genetic variants and nicotine dependence assessed in adulthood will be stronger among smokers who began daily nicotine exposure during adolescence. We compared nicotine addiction—measured by the Fagerstrom Test of Nicotine Dependence—in three cohorts of long-term smokers recruited in Utah, Wisconsin, and by the NHLBI Lung Health Study, using a candidate-gene approach with the neuronal nAChR subunit genes. This SNP panel included common coding variants and haplotypes detected in eight α and three β nAChR subunit genes found in European American populations. In the 2,827 long-term smokers examined, common susceptibility and protective haplotypes at the CHRNA5-A3-B4 locus were associated with nicotine dependence severity (p = 2.0×10−5; odds ratio = 1.82; 95% confidence interval 1.39–2.39) in subjects who began daily smoking at or before the age of 16, an exposure period that results in a more severe form of adult nicotine dependence. A substantial shift in susceptibility versus protective diplotype frequency (AA versus BC = 17%, AA versus CC = 27%) was observed in the group that began smoking by age 16. This genetic effect was not observed in subjects who began daily nicotine use after the age of 16. These results establish a strong mechanistic link among early nicotine exposure, common CHRNA5-A3-B4 haplotypes, and adult nicotine addiction in three independent populations of European origins. The identification of an age-dependent susceptibility haplotype reinforces the importance of preventing early exposure to tobacco through public health policies.


Autism Research | 2009

Twenty‐year outcome for individuals with autism and average or near‐average cognitive abilities

Megan Farley; William M. McMahon; Eric Fombonne; William R. Jenson; Judith Miller; Michael K. Gardner; Heidi Block; Carmen Pingree; Edward R. Ritvo; Riva Ritvo; Hilary Coon

Previous studies found substantial variability in adult outcome for people with autism whose cognitive functioning was within the near‐average and average ranges. This study examined adult outcome for 41 such individuals (38 men and 3 women) originally identified through an epidemiological survey of autism in Utah. Mean age at the time of their previous cognitive assessment was 7.2 years (SD=4.1, range=3.1–25.9 years) and at follow‐up was 32.5 years (SD=5.7 years, range=22.3–46.4 years). Outcome measures included standardized assessments of diagnostic status, cognitive ability, and adaptive behavior. Additional information collected concerned demographic variables, indicators of independence, social relationships, medical and psychiatric conditions, and social service use. Outcomes for this sample were better than outcomes described in previous work on individuals with similar cognitive functioning. For example, half of the participants were rated as “Very Good” or “Good” on a global outcome measure. As in previous studies, there was considerable variability in measured cognitive ability over time. Over half of the sample had large gains or losses of cognitive ability of greater than 1 standard deviation. Cognitive gain was associated with better outcome, as was better adaptive functioning. While all participants had baseline IQs in the nonimpaired range, there was limited evidence to support the use of other early childhood variables to predict adult outcome.


Neuroscience Letters | 2007

Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism.

Jee Eun Lee; Erin D. Bigler; Andrew L. Alexander; Mariana Lazar; Molly B. DuBray; Moo K. Chung; Michael Johnson; Jubel Morgan; Judith Miller; William M. McMahon; Jeffrey K. Lu; Eun Kee Jeong; Janet E. Lainhart

Recent MRI studies have indicated that regions of the temporal lobe including the superior temporal gyrus (STG) and the temporal stem (TS) appear to be abnormal in autism. In this study, diffusion tensor imaging (DTI) measurements of white matter in the STG and the TS were compared in 43 autism and 34 control subjects. DTI measures of mean diffusivity, fractional anisotropy, axial diffusivity, and radial diffusivity were compared between groups. In all regions, fractional anisotropy was significantly decreased and both mean diffusivity and radial diffusivity were significantly increased in the autism group. These results suggest that white matter microstructure in autism is abnormal in these temporal lobe regions, which is consistent with theories of aberrant brain connectivity in autism.

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Janet E. Lainhart

University of Wisconsin-Madison

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Judith Miller

Children's Hospital of Philadelphia

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