Wim Dehaen

Removal of the Uremic Retention Solute p-Cresol Using Fractionated Plasma Separation and Adsorption

Removal of protein-bound uremic retention solutes, including p-cresol, by peritoneal dialysis and hemodialysis (HD) is limited. p-Cresol, mainly circulating as sulfate conjugate (p-cresyl sulfate [PCS]), is independently associated with mortality. Fractionated plasma separation and adsorption (FPSA) is a nonbiologic detoxification system for the treatment of liver failure. The FPSA clearance of uremic retention solutes is unknown. We studied PCS clearance by FPSA, using the Prometheus system. The neutral resin adsorbent and the anion exchange adsorbent bind PCS in vitro (reduction ratios [RRs] 37 and 70%). Ex vivo, the adsorbent mass removal (MR) (median 47.5 mg) contributes more than half to total MR (median 89.6 mg). In vivo, PCS RR during FPSA (50%) exceeded the RR during high flux HD (30%). We halted the study after four inclusions due to repeated thrombosis of the arterio-venous conduit. In conclusion, FPSA is a promising technique to improve clearance of protein-bound uremic retention solutes.

The influence of molecular architecture and solvent type on the size and structure of poly(benzyl ether) dendrimers by SANS

The size of poly(benzyl ether) dendrimers with different molecular architectures was measured by small angle neutron scattering (SANS). Both polar and non-polar solvents were used to measure the effect of solvent type. The radius of gyration (Rg) of all of the dendrimers follows a scaling law of Rg M1/3 consistent with literature values of other chemically different dendrimers. The effect of solvent type on dendrimer size was minimal.

SANS study of poly(benzyl ether) dendrimers

Abstract The analysis of SANS data for a series of the poly(benzyl ether) dendrimers of different molecular architecture in deuterated tetrahydrofuran and toluene allowed to obtain information about some regularities of the relation between the topology of the dendrimer molecule and its structural parameters. The dimension of the present dendrimers of the poly(benzyl ether) type points to a scaling law of the type R g ∼ M 1/3 in line with literature information obtained for other chemically different dendrimers.

CCDC 729034: Experimental Crystal Structure Determination

Related Article: J.Thomas, W.Maes, K.Robeyns, M.Ovaere, L.Van Meervelt, M.Smet, W.Dehaen|2009|Org.Lett.|11|3040|doi:10.1021/ol901044m

Crystal structure of N-(3,5-benzenedicarboxy)-2,5-phenyl-3,4-(9,10-dihydroanthracen-diyl)-pyrrole—acetone—water (1:1:1), C38H25NO4 · C3H6O · H2O

Abstract C41H33NO6, triclinic, P1̅ (No. 2), a = 9.610(3) Å, b = 12.877(3) Å, c = 15.138(4) Å, α = 109.29(2)°, β = 105.16(2)°, γ = 94.24(2)°, V = 1680.0 Å3, Z = 2, Rgt(F) = 0.059, wRref(F2) = 0.161, T = 289 K.