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Wim Gaston Verschueren

Janssen Pharmaceutica

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Featured researches published by Wim Gaston Verschueren.

Bioorganic & Medicinal Chemistry Letters | 1995

The discovery of a series of new non-indole 5HT1D agonists

Guy Rosalia Eugene Van Lommen; Marcel Frans Leopold De Bruyn; Marc Francis Josephine Schroven; Wim Gaston Verschueren; W. J. Janssens; Jan Verrelst; Josée E. Leysen

Abstract The synthesis and SAR of a series of non-indole 5HT1D agonists is described. The most interesting molecule of this series is compound 13, alniditan. It is active as a constrictor of the saphenous vein of the dog and of the pig basilar artery with ED50 values of 9.09×10−9M and 2.29×10−8M respectively, and it has high affinities to the 5HT1D-receptor and to the 5HT1D-receptor with pKi values of 8.6 and 8.3 respectively.

Archive | 1998

(benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties

Piet Tom Bert Paul Wigerinck; Wim Gaston Verschueren; Marc Francis Josephine Schroven; Marcel Frans Leopold De Bruyn

Archive | 1994

Vasoconstrictive dihydrobenzopyran derivatives

Guy Rosalia Eugene Van Lommen; Piet Tom Bert Paul Wigerinck; Marcel Frans Leopold De Bruyn; Wim Gaston Verschueren; Marc Francis Josephine Schroven

Archive | 2012

Hetero-bicyclic derivatives as HCV inhibitors

Koen Vandyck; Wim Gaston Verschueren; Pierre Jean-Marie Bernard Raboisson

Archive | 2013

4,4-DISUBSTITUTED-1,4-DIHYDROPYRIMIDINES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Koen Vandyck; Geerwin Yvonne Paul Haché; Geert Rombouts; Wim Gaston Verschueren; Pierre Jean-Marie Bernard Raboisson

Archive | 2000

Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives

Marcel Frans Leopold De Bruyn; Kristof Van Emelen; Piet Tom Bert Paul Wigerinck; Wim Gaston Verschueren

Archive | 2013

FUSED BICYCLIC SULFAMOYL DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Koen Vandyck; Wim Gaston Verschueren; Pierre Jean-Marie Bernard Raboisson

Archive | 2016

SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Koen Vandyck; Geerwin Yvonne Paul Haché; Geert Rombouts; Wim Gaston Verschueren; Pierre Jean-Marie Bernard Raboisson

Archive | 2007

HOMOGENEOUS TIME RESOLVED FLUORESCENCE BASED TEST SYSTEM

Géry Karel Julia Dams; Inge Vereycken; Koenraad Lodewijk August Van Acker; Emmanuel Gustin; Wim Gaston Verschueren; Åsa Catrine Ohagen

Archive | 2015

GLYOXAMIDE SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Koen Vandyck; Bart Rudolf Romanie Kesteleyn; Serge Maria Aloysius Pieters; Geert Rombouts; Wim Gaston Verschueren; Pierre Jean-Marie Bernard Raboisson

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Collaboration

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Koen Vandyck

Tibotec

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Guy Rosalia Eugene Van Lommen

Janssen Pharmaceutica

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William R. Lutz

Janssen Pharmaceutica

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Pierre Jean-Marie Bernard Raboisson

Centre national de la recherche scientifique

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Piet Tom Bert Paul Wigerinck

Janssen Pharmaceutica

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Marc Francis Josephine Schroven

Janssen Pharmaceutica

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Victor Sipido

Janssen Pharmaceutica

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Pierre Jean-Marie Bernard Raboisson

Centre national de la recherche scientifique

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Geerwin Yvonne Paul Haché

Janssen Pharmaceutica

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Marcel Frans Leopold De Bruyn

Janssen Pharmaceutica

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