Won Sick Woo

Pharmacological study on piperine

Systematic pharmacological studies on piperine have revealed that this compound elicited diverse pharmacological activities; CNS depressant activity characterized by antagonism against electroshock seizure and by muscle relaxant activity in mice; antipyretic activity in typhoid vaccinated rabbits; analgesic activity as evaluated by tail-clip pressure and writhing syndrome in mice; antiinflammatory activity in carrageenin-induced edema in rats.

The structure of macelignan from Myristica fragrans

Abstract A new lignan, macelignan, isolated from the arils of Myristica fragrans , is shown to have the structure (2 R ,3 S )-1-(3,4-methylenedioxyphenyl)-2,3-dimethyl-4-(4-hydroxy-3-methoxyphenyl)-butane by spectral analysis, chemical conversion and X-ray crystallographic analysis.

Flavonoids from the leaves ofRhododendron brachycarpum

The flavonoids isolated from the leaves ofRhododendron brachycarpum, were identified as quercetin, avicularin, quercitrin and hyperin.

The structure of new lignans from the seeds of phytolacca americana

Abstract From the seeds of Phytolacca americana two new lignans, Americanin B and D, have been isolated and their structures elucidated mainly by spectroscopic methods

Sterol and triterpenoid glycosides from the roots of Patrinia scabiosaefolia

Abstract From the roots of Patrinia scabiosaefolia , oleanolic acid, hederagenin, 3- O -α- l -arabinopyranosyl-oleanolic acid, 3- O -α- l -arabinopyranosyl-hederagenin, 2′- O -acetyl-3- O -α- l -arabinopyranosyl-hederagenin and a mixture of sitosterol and campesterol- d -glucosides were isolated.

Isolation of hepatic drug metabolism inhibitors from the seeds ofMyristica fragrans

The hexane extract from Nutmeg, the seed ofMyristica fragrans significantly inhibited hepatic drug-metabolizing enzyme activity. Through systematic fractionation by SiO2 column and vacuum liquid chromatography monitoring by bioassay, three components, myristicin, (I), licarin-B(II) and dehydrodiisoeugenol(III) were isolated as active principles. Compounds II and III, with a single treatment (200 mg/kg, i.p.) showed not only a significant prolongation of hexobarbital-induced sleeping time but also a significant inhibition of aminopyrine N-demethylase and hexobarbital hydroxylase activities in mice. Compounds I and II provoked a sleep episode at a subhypnotic dose of HB, suggesting that they posses CNS-depressant properties.

Sedative action of spinosin

The acute toxicity and the sedative action of spinosin isolated fromZizyphus seeds have been tested with mice.Spinosin possessed a very weak toxicity and at relatively high dose showed a significant sedative action in a ladder-climbing test, a potentiation of hexobarbital-induced hypnosis and an antagonistic effect on caffeine-induced hyperactivity.

Phytolaccoside B: Triterpene glucoside from Phytolacca americana

Abstract The structure of phytolaccoside B, one of the major saponin components of the roots of Phytolacca americana, has been elucidated as 3β- d -glucopyranosyljaligonic acid 30-methyl ester.

Biological Evaluation of Korean Medicinal Plants(III)

The extracts of sixty Korean plants were evaluated for their biological activities such as antitumor activities against Sarcoma 180, Leukemia SN-36 and Ehrlich ascites carcinoma, antimicrobial activities and behavioral observation in mice. The results are tabulated.

Coumarins and triterpenoid glycosides from the roots ofPatrinia scabiosaefolia

From the roots ofPatrinia scabiosaefolia (Valerianaceae), scopoletin (1), esculetin (2), oleanonic acid (3), 3-O-α-l-rhamnopyranosyl(1→2)-α-l-arabinopyranosyl oleanolic acid (4) and 3-O-α-l-rhamnopyranosyl (1→2)-α-l-arabinopyranosyl hederagenin (5) were isolated and characterized by spectral data.