Xiaolei Yu
Wuhan University
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Publication
Featured researches published by Xiaolei Yu.
Applied Physics Letters | 2010
Xiangheng Xiao; Feng Ren; Xiaodong Zhou; T Peng; Wei Wu; X. N. Peng; Xiaolei Yu; Changzhong Jiang
The Ag nanoparticles-SiO2–ZnO film sandwiched structure was fabricated by depositing ZnO films on silica substrates which had been implanted by Ag ions. Enhancement of emission of the sandwiched structure was observed. The enhancement emission is caused by the resonant coupling between the surface plasmons of Ag and the spontaneous emission of ZnO. The enhancement mechanism is confirmed by optical absorption spectra, transmission electron microscopy, and time-resolved photoluminescence. The key is to deposit ZnO on Ag nanoparticles covered with silica to prevent oxidation of Ag by direct contact with ZnO. This structure will be very useful for highly efficient optoelectronic devices.
Applied Physics Letters | 2015
H. J. Liu; Xiaolei Yu; Bo Cai; Sujian You; Zhaobo He; Qinqin Huang; Lang Rao; Shasha Li; Chang Liu; Weiwei Sun; Wei Liu; Shishang Guo; Xingzhong Zhao
This paper introduces a cancer cell capture/release microchip based on the self-sacrificed MnO2 nanofibers. Through electrospinning, lift-off and soft-lithography procedures, MnO2 nanofibers are tactfully fabricated in microchannels to implement enrichment and release of cancer cells in liquid samples. The MnO2 nanofiber net which mimics the extra cellular matrix can lead to high capture ability with the help of a cancer cell-specific antibody bio-conjugation. Subsequently, an effective and friendly release method is carried out by using low concentration of oxalic acid to dissolve the MnO2 nanofiber substrate while keeping high viability of those released cancer cells at the same time. It is conceivable that our microchip may have potentials in realizing biomedical analysis of circulating tumor cells for biological and clinical researches in oncology.
Applied Physics Letters | 2015
Lingling Zhang; Xiaolei Yu; Sujian You; H. J. Liu; Cancan Zhang; Bo Cai; Liang Xiao; Wei Liu; Shishang Guo; Xingzhong Zhao
A microfluidic flow sensor based on aligned piezoelectric poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] nanofibers has been developed. The flow sensor is able to linearly measure low flow rates ranging from 13 μl/h to 301 μl/h with a sensitivity of 0.36 mV per 1 μl/h, and the highest voltage difference of 120 mV at a flow rate of 451 μl/h. Moreover, the viscosity of the ethylene glycol aqueous solution ranging from 1 mPa·s to 16.1 mPa·s at 25 °C can be detected in dynamic flow with a stable output. These findings highlight the potential of piezoelectric P(VDF-TrFE) nanofibers in multiferroic applications.
AIP Advances | 2015
Lang Rao; Bo Cai; Xiaolei Yu; Shishang Guo; Wei Liu; Xingzhong Zhao
3D microelectrodes are one-step fabricated into a microfluidic droplet separator by filling conductive silver paste into PDMS microchambers. The advantages of 3D silver paste electrodes in promoting droplet sorting accuracy are systematically demonstrated by theoretical calculation, numerical simulation and experimental validation. The employment of 3D electrodes also helps to decrease the droplet sorting voltage, guaranteeing that cells encapsulated in droplets undergo chip-based sorting processes are at better metabolic status for further potential cellular assays. At last, target droplet containing single cell are selectively sorted out from others by an appropriate electric pulse. This method provides a simple and inexpensive alternative to fabricate 3D electrodes, and it is expected our 3D electrode-integrated microfluidic droplet separator platform can be widely used in single cell operation and analysis.
Applied Physics Letters | 2015
Chang Liu; Bo Hua; Sujian You; Chenghao Bu; Xiaolei Yu; Zhenhua Yu; Nian Cheng; Bo Cai; H. J. Liu; Shasha Li; Lingling Zhang; Sheng-Xiang Wang; Kan Liu; Nangang Zhang; Wei Liu; Shishang Guo; Xingzhong Zhao
A piezoelectric nanogenerator with self-amplified output is prepared with a polydimethylsiloxane (PDMS)/silver nanowire (Ag NW)/poly(vinylidene fluoride-trifluoroethylene) sandwich structure. The Ag NWs facilitate the collection of induced charge generated by the piezoelectric film, and the micro-patterned PDMS films multiply the devices sensitivity under external compression. The nanogenerator exhibits good performance, with a peak open circuit voltage of 1.2 V, and a peak short circuit current of 82 nA. These findings highlight the potential of the nanogenerator in self-powered devices and wearable energy harvesters.
Applied Physics Letters | 2016
Xiaolei Yu; Cancan Zhang; Sujian You; H. J. Liu; Lingling Zhang; Wei Liu; Shishang Guo; Xingzhong Zhao
Aiming to synthesize multiferroic materials in microscale, a microfluidic device capable of generating multiferroic Janus microparticles is demonstrated. Through bonding two polydimethylsiloxane (PDMS) layers “face to face,” laminar flow containing an upper layer and a lower layer can be realized. Accordingly, poly(vinylidene fluoride-trifluoroethylene) ferroelectric polymers and Fe3O4 ferromagnetic particles are separately encapsulated in the two layers of a single droplet. Numerical simulation enables the analysis of cross-mixing between the two counterparts and helps to find an optimized location for adding subsequent ultraviolet treatment, which will polymerize the droplets into Janus particles without any side effect. By modulation of the flow rate, the size of the Janus particles can be precisely tuned. Finally, the ferroelectricity and magnetism of the Janus particles are verified by the magnetization and polarization measurements, indicating the multiferroic nature.
Applied Physics Letters | 2014
Shasha Li; Xiaolei Yu; Sujian You; Bo Cai; Chang Liu; H. J. Liu; Wei Liu; Shishang Guo; Xingzhong Zhao
We report on the feasible generation of BiFeO3-Fe3O4 Janus particles (JPs) based on droplet microfluidic method. Utilizing laminar flow and flow-focusing in microchannels, BiFeO3 and Fe3O4 nanoparticles were separately embedded in each hemisphere of one hydrogel particle. The size of the Janus particles showed favorable uniformity at micron scale and could be precisely controlled by flow rate regulation. The magnetism and ferroelectricity of the JPs were confirmed by magnetization and polarization measurements, indicating potential in multiferroic applications.
Journal of Materials Chemistry B | 2017
Zhaobo He; Feng Guo; Chun Feng; Bo Cai; James P. Lata; Rongxiang He; Qinqin Huang; Xiaolei Yu; Lang Rao; H. J. Liu; Shishang Guo; Wei Liu; Yuanzhen Zhang; Tony Jun Huang; Xingzhong Zhao
Cell-free DNA has been widely used in non-invasive prenatal diagnostics (NIPD) nowadays. Compared to these incomplete and multi-source DNA fragments, fetal nucleated red blood cells (fNRBCs), once as an aided biomarker to monitor potential fetal pathological conditions, have re-attracted research interest in NIPD because of their definite fetal source and the total genetic information contained in the nuclei. Isolating these fetal cells from maternal peripheral blood and subsequent cell-based bio-analysis make maximal genetic diagnosis possible, while causing minimal harm to the fetus or its mother. In this paper, an affinity microchip is reported which uses hydroxyapatite/chitosan nanoparticles as well as immuno-agent anti-CD147 to effectively isolate fNRBCs from maternal peripheral blood, and on-chip biomedical analysis was demonstrated as a proof of concept for NIPD based on fNRBCs. Tens of fNRBCs can be isolated from 1 mL of peripheral blood (almost 25 mL-1 in average) from normal pregnant women (from the 10th to 30th gestational week). The diagnostic application of fNRBCs for fetal chromosome disorders (Trisomy 13 and 21) was also demonstrated. Our method offers effective isolation and accurate analysis of fNRBCs to implement comprehensive NIPD and to enhance insights into fetal cell development.
Electrophoresis | 2011
Wei Cheng; Sizhe Li; Qian Zeng; Xiaolei Yu; Yu Wang; Helen L. W. Chan; Wei Liu; Shishang Guo; Xingzhong Zhao
We present a feasible dielectrophoresis (DEP) approach for rapid patterning of microparticles on a reusable double‐layer electrode substrate in microfluidics. Simulation analysis demonstrated that the DEP force was dramatically enhanced by the induced electric field on top interdigitated electrodes. By adjusting electric field intensity through the bottom electrodes on thin glass substrate (100 μm), polystyrene particles (10 μm) were effectively patterned by top electrodes within several seconds (<5 s). The particle average velocity can reach a maximum value of about 20.0±3.0 μm/s at 1 MHz with the strongest DEP force of 1.68 pN. This approach implements integration of functional electrodes into one substrate and avoids direct electrical connection to biological objects, providing a potential lab‐on‐chip system for biological applications.
Small | 2015
Lang Rao; Lin-Lin Bu; Jun-Hua Xu; Bo Cai; Guang-Tao Yu; Xiaolei Yu; Zhaobo He; Qinqin Huang; Andrew Li; Shishang Guo; Wen-Feng Zhang; Wei Liu; Zhi-Jun Sun; Hao Wang; Tza-Huei Wang; Xing-Zhong Zhao