Xiaolong Qi

Primary synovial sarcoma of the prostate metastatic to the liver and lung: a case report

Primary synovial sarcoma of the prostate is an uncommon malignant tumor. There are few cases reported in the English medical literature to date. Here, we present a case of 22-year-old man with primary synovial sarcoma of the prostate metastatic to the liver and lung. To our knowledge, only six reports of synovial sarcoma involving the prostate have been previously published. We also reviewed the previous treatments and prognoses in previous case reports and evaluate the proper treatment for this disease.

Effect of NQO1 C609T polymorphism on prostate cancer risk: a meta-analysis.

Background Some studies have found that the NAD(P)H:quinone oxidoreductase 1 (NQO1) SNP609 is associated with an increased risk for several malignancies. Numerous epidemiological studies have evaluated the association between the NQO1 C609T polymorphism and the risk of prostate cancer. However, the results of these studies have been conflicting. The aim of this study was to provide a more precise estimation of its relationship with prostate cancer using a meta-analysis. Methods Electronic searches of several databases were conducted for all publications on the association between the NQO1 C609T polymorphism and prostate cancer before May 2013. The odds ratio (OR) and its 95% confidence interval (CI) were used for statistical analysis. Results A total of six studies with 717 cases and 1,794 controls were included. No significant association was found between the NQO1 C609T polymorphism and prostate cancer risk in the total population analysis. In subgroup meta-analysis by ethnicity, a positive association was found in an Asian subgroup (T versus C, OR 1.337, 95% CI 1.014–1.763, P=0.040; TT + CT versus CC, OR 1.419, 95% CI 1.053–1.913, P=0.021). However, no significant association in any genetic models was observed in Caucasians. Conclusion This meta-analysis showed that the NQO1 SNP609 T allele might be a risk factor for prostate cancer in Asians. However, this result should be verified by additional population-based studies with large sample sizes.

Effect of the CCND1 A870G polymorphism on prostate cancer risk: a meta-analysis of 3,820 cases and 3,825 controls

BackgroundCyclin D1 (CCND1) is critical in the transition of the cell cycle from the G1 to S phases, and unbalanced cell cycle regulation is a hallmark of carcinogenesis. Numerous epidemiological studies have evaluated the association between the CCND1 A870G polymorphism and the risk of prostate cancer (PCa). However, these studies have yielded conflicting results.MethodsIn the present study, the possible association above was assessed by a meta-analysis. Eligible articles were identified for the period up to July 2014. Pooled odds ratios (ORs) with 95% confidence intervals (95% CI) were appropriately derived from fixed effects or random effects models.ResultsA total of ten case-control studies, which included 3,820 cases and 3,825 controls, were identified. Overall, the allelic/genotypic association between the G870A polymorphism and prostate cancer was nonsignificant (OR = 1.045, 95% CI = 0.947 to 1.153 for A versus G, P = 0.380; OR = 1.088, 95% CI = 0.896 to 1.321 for AA versus GG, P = 0.393; OR = 1.044, 95% CI = 0.941 to 1.158 for GA versus GG, P = 0.414; OR = 1.053, 95% CI = 0.955 to 1.161 for the dominant model AA + GA versus GG, P = 0.303; OR = 1.072, 95% CI = 0.881 to 1.306 for the recessive model AA versus AA + GA, P = 0.486). Moreover, subgroup analyses according to ethnicity failed to demonstrate a significant association between this polymorphism and prostate cancer. In addition, we also performed a stratified analysis of cases with PCa metastasis, and the results supported the findings of no significant association between CCND1 A870G polymorphism and metastasis risk of PCa.ConclusionsOur results suggest that the CCND1 A870G polymorphism might not be a potential candidate for predicting prostate cancer risk, including metastasis risk.

Laparoscopic heminephrectomy of a horseshoe kidney with giant renal cell carcinoma: A case report

A 72-year-old male was diagnosed incidentally with a 7-cm renal tumor in the right moiety of a horseshoe kidney during a routine physical examination, and was treated with laparoscopic radical heminephrectomy. The surgical time was 153 min and the estimated blood loss was 150 ml. The patient was discharged on post-operative day eight with no complications. Computed tomography angiography is desirable prior to surgery for the evaluation of the anatomical variations of horseshoe kidneys, and a pre-operative understanding is necessary for achieving reliable vascular control. In conclusion, the present technique is safe and effective for this complex clinical condition.

Correction to: Robot-assisted laparoscopic reconstructed management of multiple aneurysms in renal artery primary bifurcations: a case report and literature review

CorrectionAfter publication of this work [1] it was noticed the author – Jie Wang’s name was in the wrong order.The original article was corrected.The publisher apologises for this error.

AB054. An improved technique for bladder cancer: pure laparoscopic radical cystectomy with orthotopic U-shape ileal neobladder using titanium staples

Objective To report our experience with an improved technique of laparoscopic radical cystectomy (LRC) and orthotopic ileal neobladder reconstruction, evaluating the perioperative and pathological outcomes. Methods We retrospectively reviewed the data of 56 cases who underwent radical cystoprostatectomy followed by construction of an orthotopic U-shaped ileal neobladder between August 2010 and December 2014. These data include intraoperative data, early and long-term postoperative complications, neobladder function, urinary continence and oncologic results. Also the key innovative procedure was introduced with details. Results The median time of the overall procedure was 212 min. The median estimated blood loss was 171 mL. The median hospitalization time after the operation was 21 days. Complications included two cases of unilateral ureter-pouch anastomotic strictures, one case of bilateral ureteral stricture, three cases of vesicourethral anastomotic strictures and three cases of vesicourethral leakage. The mean maximum pouch capacity was 446±32 mL, and pouch pressure at capacity was 18.1±2.6 cmH2O. The Qmax was 14±1.2 mL/s, and the mean post-void residual was 25±10 mL. There were nine cases of night-time incontinence at 3 months post-operatively. Negative surgical margins of the bladder specimens were achieved in all patients. During a follow-up period of 3 to 44 months (average 32.6 months), local recurrence was found in two patients and distant metastasis was occurred in another three patients. Conclusions Our preliminary experience showed that pure LRC with non-absorbable titanium staples assisted orthotopic U-shape ileal neobladder reconstruction is feasible based on perioperative data and oncologic features.

AB058. Clinic practice of the laparoscopic ileal bladder augmentation

Objective To investigate the efficacy and safety of laparoscopic ileal bladder augmentation in treating patients with low compliant bladder dysfunction. Methods From June 2011 to December 2013, 22 patients with low compliant bladder dysfunction were enrolled and received laparoscopic ileal bladder expanding. Postoperative complications, renal function, hydronephrosis, glomerular filtration rate, urodynamics parameters and quality of daily life were evaluated. Results The laparoscopic ileal bladder expanding were all successful. The average operation time was (105.0±16.7) min, the bleeding volume was (90.0±26.0) mL, the recovery time of intestinal function was (2.5±0.7) days, the hospitalization time was (15.0±4.2) days. All the patients had no serious complications, such as ileum anastomotic fistula, intestinal obstruction and abdominal infection or sepsis. Among them, 17 patients were followed up for more than 12 months. Compared with the preoperative condition, the average bladder capacity and bladder compliance were significantly increased from (103.0±38.2) cmH2O to (403.0±45.8) cmH2O, and from (9.6±3.1) to (38.1±4.4) mL/cmH2O (P<0.001), respectively. And the average bladder pressure at the end of filling phrase of cystometry were significantly decreased from (45.3±15.8) cmH2O to (16.5±6.4) cmH2O (P<0.001). The preoperative and postoperative serum creatinine level were (183.5±32.2) μmol/L and (120±28.4) μmol/L (P<0.001), respectively. The preoperative and postoperative total glomerular filtration rate were (40.0±25.5) mL/min/1.73m2 and (62.0±28.6) mL/min/1.73m2 (P<0.05), respectively. Conclusions The operation of laparoscopic ileal bladder expanding is feasible and security, with the advantages of little injury, less bleeding, quicker recovery of intestinal function and less postoperative complications. The bladder function was obviously improved after operations, which can effectively protect the patient’s upper tract functions.