Xuan Lu

Two new compounds from the broth of the marine fungus Penicillium griseofulvum Y19-07

Two new compounds, 4-hydroxyphenethyl methyl succinate (1) and 4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (2), were isolated from the EtOAc extract of the broth of the marine fungus Penicillium griseofulvum Y19-07. Five known compounds were also obtained in this study. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for their scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl free radical by spectroscopic assays. Also, in the cytotoxicity assay of the two new compounds against HL-60 and PC-3 prostate cancer cell lines, compound 2 showed potential activity with an IC50 value of 64.5 μM against human HL-60 cancer cells.

Furostanol saponins from the fruits of Tribulus terrestris

Two new steroidal saponins were isolated from the fruits of Tribulus terrestris. Their structures were assigned by spectroscopic analysis and colour reaction as 26-O-β-D-glucopyranosyl-(25R)-5α-furostane-12-one-3β,22α,26-triol-3-O-β-D-glucopyranosyl(1 → 4)-β-D-galactopyranoside (1); 26-O-β- D-glucopyranosyl-25(R)-5α-furostan-12-one-3β,22α,26-triol-3-O-α-L-rhamnopyranosyl-(1 → 2)-O-[β-D-glucopyranosyl-(1 → 4)]-β-D-galactopyranoside (2).

Aromatic compounds from endophytic fungus Colletotrichum sp. L10 of Cephalotaxus hainanensis Li

Six aromatic compounds were isolated from the endophytic fungus Colletotrichum sp. of Cephalotaxus hainanensis Li [Cephalotaxus mannii Hook. f.]. Their structures were determined on the basis of chemical and spectroscopic methods. The compound 2 was the enantiomer of compound 1. The compound 4 was the epimeride of the compound 3. The compounds 1, 2, 4 and 5 were evaluated for cytostatic activity against HL-60 and PC-3 cells.

New steroidal glycosides from Tribulus terrestris L.

Two new steroidal glycosides were isolated from Tribulus terrestris L. Their structures were elucidated as 26-O-β-d-glucopyranosyl-5α-furostan-12-one-20(22)-ene-3β,23,26-triol-3-O-β-d-xylopyranosyl-(1 → 2)-[β-d-xylopyranosyl-(1 → 3)]-β-d-glucopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-galactopyranoside (1) and 26-O-β-d-glucopyranosyl-5α-furostan-20(22)-ene-3β,23,26-triol-3-O-β-d-xylopyranosyl-(1 → 2)-[β-d-xylopyranosyl-(1 → 3)]-β-d-glucopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-galactopyranoside (2) by spectroscopic methods including 1D and 2D NMR experiments.

Two new steroidal saponins from Tribulus terrestris L.: Original article

Two new steroidal saponins were isolated from the fruits of Tribulus terrestris L. Their structures were elucidated by spectroscopic and chemical analysis as (23S,24R,25R)-5α-spirostane-3β,23,24-triol-3-O-{α-l-rhamnopyranosyl-(1 → 2)-[β-d-glucopyranosyl-(1 → 4)]-β-d-galactopyranoside} (1) and (23S,24R,25S)-5α-spirostane-3β,23,24-triol-3-O-{α-l-rhamnopyranosyl-(1 → 2)-[β-d-glucopyranosyl-(1 → 4)]-β-d-galactopyranoside} (2).

Three new compounds from the marine-derived fungus Trichoderma atroviride G20-12

Three new compounds, 4′-(4,5-dimethyl-1,3-dioxolan-2-yl)methyl-phenol (1), (3′-hydroxybutan-2′-yl)5-oxopyrrolidine-2-carboxylate (2), and atroviridetide (3), have been isolated from the marine-derived fungus Trichoderma atroviride G 20-12. Their structures were determined on the basis of chemical and spectroscopic methods.

Chemical constituents from the fruits of Trichosanthes kirilowii

Two new compounds, 1-deoxy-1-[2′-oxo-1′-pyrrolidinyl]-2-n-butyl-α-fructofuranoside (1) and isoarvenin III (2), were isolated from the fruits of Trichosanthes kirilowii Maxim, and their structures were established on the basis of spectroscopic methods.

Two new steroidal glycosides from Cynanchum amplexicaule

Two new C21 steroidal glycosides were isolated from the EtOAc fraction of Cynanchum amplexicaule. Their structures were elucidated as amplexicogenin d-3-O-β-d-cymaropyranoside (1) and stauntogenin -3-O-α-l-oleandropyranosyl-(1 → 4)-O-β-d-digitoxopyranosyl-(1 → 4)-O-β-d-oleandropyranoside (2) by spectroscopic analysis including 1D and 2D NMR experiments.

Two new compounds from the fruits of Trichosanthes kirilowii Maxim.

Two new compounds 1,3-O-[5-(hydroxymethyl)-furan-2-yl]methenyl-2-n-butyl-α-fructofuranoside (1) and n-butyl-3,4-dihydroxyl-5-hydroxymethyl-4-O-[5-(hydroxymethyl)-furan-2-yl]-tetrahydrofuran-2-carboxylate (2) were isolated from the fruits of Trichosanthes kirilowii Maxim, and their structures were established on the basis of spectroscopic methods.

Three new compounds from Dictamnus dasycarpus

Phytochemical investigation of the ethyl acetate extracts from root barks of Dictamnus dasycarpus led to the isolation of three new compounds, named as dasycarpusenester A (1), dasycarpusester B (2), dasycarpusacid (3). Their structures were elucidated as (2S)-4-(2,2-dimethyl-5-oxotetrahydrofuran-3-yl)-2-hydroxypent-3-enoic acid methyl ester (1), (2R)-4-(2,2-dimethyl-5-oxotetrahydrofuran-3-yl)-2-hydroxypent-3-anoic acid methyl ester (2), and (2S)-4-(2,2-dimethyl-5-oxotetrahydrofuran-3-yl)-2-hydroxypent-3-anoic acid (3), respectively, on the basis of modern spectroscopic methods and chemical analysis.