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Featured researches published by Yang-Chih Lin.


International Journal of Dermatology | 2007

Hydroa vacciniforme-like Epstein-Barr virus-associated monoclonal T-lymphoproliferative disorder in a child

Yu-Hung Wu; Hsiu-Chin Chen; Pa-Fan Hsiao; Mei-Ing Tu; Yang-Chih Lin; Tao-Yuan Wang

Hydroa vacciniforme (HV) is a chronic photosensitivity disorder induced by ultraviolet radiation. Hydroa vacciniforme‐like lymphoma is a rare cutaneous T‐cell lymphoma occurring mainly in childhood. Recent studies have demonstrated an association between chronic latent Epstein‐Barr virus (EBV) infection and both the benign skin disorder and the lymphoma. The authors report a 6‐year‐old boy with chronic EBV infection, HV‐like skin eruptions, and chronic hepatitis. Histopathologic examination of a skin biopsy specimen demonstrated epidermal ballooning degeneration and dense superficial and deep perivascular and periappendageal lymphoid cell infiltrates extending to the fat lobules. Some blood vessels in the deep plexus were infiltrated by predominantly CD4+ and TIA‐1+ cytotoxic T cells. The EBV genomes were found within tissue from three skin biopsies and peripheral blood cells. Monoclonal T‐cell receptor gene rearrangement was present in skin biopsy specimens. Although no lymphoma has been found during 2 years of follow‐up treatment, the possibility of lymphoma developing out of the current smoldering stage is of concern. The clinical manifestations of lymphoproliferative disorder and chronic active EBV infection are discussed.


Dermatologic Surgery | 2010

Recurrent Digital Glomus Tumor: Analysis of 75 Cases

Yang-Chih Lin; Pa‐Fan Hsiao; Yu-Hung Wu; Fang‐Ju Sun; Richard K. Scher

BACKGROUND Glomus tumors are rare, benign, cutaneous neoplasms that must be excised completely to prevent recurrence. OBJECTIVE To investigate factors associated with recurrence of glomus tumors after surgery. METHODS AND MATERIALS Fifty‐eight women and 17 men with digital glomus tumors underwent surgery between 1990 and 2008 at our hospital. These cases were retrospectively analyzed. RESULTS Mean age at diagnosis was 41.8, with an average diagnostic delay of 3.9 years. The tumor was located on a finger in 70 cases (right, 29; left, 41) and a toe in five (right, 3; left, 2). The tumor recurred in 13 (17%) patients. Recurrence was more likely if the tumor was skin‐colored (odds ratio (OR)=31.67, 95% confidence interval (CI)=2.68–373.74, p=.006) or located within the nail matrix (OR=5.79, 95% CI=1.03–32.49, p=.046). No recurrence occurred in patients who had had preoperative magnetic resonance imaging or ultrasound studies. CONCLUSION Skin‐colored tumors or those in the nail matrix are at higher risk of recurrence. The authors have indicated no significant interest with commercial supporters.


Dermatologic Surgery | 2008

Nail Changes and Association of Osteoarthritis in Digital Myxoid Cyst

Yang-Chih Lin; Yu-Hung Wu; Richard K. Scher

BACKGROUND Digital myxoid cyst is relatively common on the digits. Nail changes and osteoarthritis are usually associated with this pathogenesis. OBJECTIVE The objective was to clarify this relationship and its significance by analyzing the clinical, radiologic, and pathologic data. METHODS AND MATERIALS Fifty-one patients with digital myxoid cysts were diagnosed and analyzed during a 5-year period. RESULTS Thirty-eight (74.5%) of 51 patients showed radiologic evidence of primary interphalangeal joint osteoarthritis in the affected digits. Among the 39 cysts removed surgically and examined pathologically, 28 were myxomatous and 11 were ganglion. Different clinical manifestations of nail change, including longitudinal grooves (20 cases), concave canaliform dystrophy (9 cases), “washboard” transverse lines (5 cases), and longitudinal grooves with beaded ridges (1 case) were found. CONCLUSION Osteoarthritis of the adjacent terminal joint is an important factor involved in forming digital myxoid cysts. Of the two cyst types, ganglion cysts are related to osteoarthritis more often than myxomatous cysts. Nail changes, secondary to matrix damage, are reliable clinical signs of underlying cyst formation. Understanding the pathogenesis of the digital myxoid cyst in relation to osteoarthritis and nail deformity helps inform the care of these patients.


Journal of Cutaneous Pathology | 2006

Verruciform xanthoma-like phenomenon in seborrheic keratosis.

Yu-Hung Wu; Pa‐Fan Hsiao; Yang-Chih Lin

Abstract:  Verruciform xanthoma is xanthomatous dermal infiltrate in a proliferating epidermal lesion and is an uncommon phenomenon. It has been reported in various neoplastic or inflammatory conditions. We report a 72‐year‐old man who had an asymptomatic 1‐cm black nodule on his abdomen. Histopathology showed a typical acanthotic type of seborrheic keratosis characterized by basaloid keratinocyte proliferation and pseudohorn cysts. Many aggregated xanthomatized cells were seen in dermal papillae within the acanthotic epithelium. Papillomatosis, parakeratosis, and neutrophil infiltrates, the histologic features of typical verruciform xanthoma, were not seen. The foamy cells were positive for CD‐68 and vimentin and negative for cytokeratin and S‐100. No human papillomavirus DNA was found by nested polymerase chain reaction. The blood lipid profile was normal. The presence of verruciform xanthomatous change in seborrheic keratosis provides further evidence that verruciform xanthoma may be a reactive phenomenon occurring in common skin disorders.


Journal of Cutaneous Pathology | 2003

Subungual pleomorphic fibroma

Ya-Ju Hsieh; Yang-Chih Lin; Yu-Hung Wu; Hsin-Yi Su; Steven D. Billings; Antoinette F. Hood

Background:  Pleomorphic fibroma is a benign fibroblastic tumor characterized by pleomorphic, hyperchromatic cells or giant multinucleated cells embedded in a collagenous stroma. These cytologic features may lead to an incorrect diagnosis of malignancy. Most cases reported in the literature are located on trunk or extremities; the presentation as a subungual mass is rare.


Journal of Cutaneous Pathology | 2007

Cytoid bodies in cutaneous direct immunofluorescence examination.

Yu-Hung Wu; Yang-Chih Lin

Background:  The clinical significance of scattered or grouped cytoid bodies seen on direct immunofluorescence (DIF) examination has not been systematically analyzed in a variety of disorders.


Journal of Cutaneous Pathology | 2009

Necrolytic acral erythema without hepatitis C infection

Yu-Hung Wu; Mei-Eng Tu; Chyou-Shen Lee; Yang-Chih Lin

Necrolytic acral erythema is a newly described entity characterized by sharply demarcated scaly plaques on the dorsum of the hands and feet. More than 30 patients have been reported since 1996, all of whom had anti‐hepatitis C virus antibody. A 32‐year‐old Taiwanese woman had been diagnosed with and treated for systemic lupus erythematosus with lupus nephritis about 10 years earlier. Soon thereafter, she noted several well‐demarcated keratotic plaques with erythematous borders on her feet, with sparing of the soles. Histopathology showed diffuse parakeratosis with a neutrophil infiltrate, hypogranulosis, pale upper keratinocytes, scattered and grouped dyskeratotic cells, psoriasiform hyperplasia and a mild lymphocytic infiltrate in the upper dermis. The diagnosis was made after three biopsies. The lesions regularly worsened just before and during menstruation, but patch and intradermal tests for progesterone and estrogen were negative. There was no evidence of either hepatitis B or hepatitis C infection. The lesions did not respond to treatment with zinc. The rash regressed spontaneously when corticosteroids were stopped and recurred when they were restarted, finally resolving completely after she was treated with high‐dose pulse steroids for her lupus.


International Journal of Dermatology | 2011

Relapsing polychondritis complicated with Sweet's syndrome and normolipemic neutrophilic xanthomatosis successfully treated by dapsone.

Po-Hsuan Lu; Yang-Chih Lin; Yu-Hung Wu

Relapsing polychondritis is a rare disorder characterized by recurrent episodes of inflammation and degeneration of cartilaginous tissues. Sweet’s syndrome is characterized by recurrent painful inflammatory papules, fever, leukocytosis, diffuse neutrophilic infiltrate, and good response to systemic glucocorticoids. Normolipemic xanthoma is defined by xanthoma identified in a normolipemic patient. We report a patient with normolipemic neutrophilic xanthomatosis, Sweet’s syndrome, and relapsing polychondritis that improved rapidly with dapsone. A 70-year-old man had yellowish papules on his chest and abdomen two years after the onset of relapsing polychondritis (Fig. 1a). Histopathologic examination of a skin biopsy specimen demonstrated foamy cells in the


British Journal of Dermatology | 2007

Hydroxyzine-induced acute generalized exanthematous pustulosis

Tsai Ys; Mei-Eng Tu; Yu-Hung Wu; Yang-Chih Lin

1 French LE, Prins C. Toxic epidermal necrolysis. In: Dermatology (Bolognia JL, Jorizzo JL, Rapini RP, eds). Philadelphia: Elsevier Mosby, 2003; 323–31. 2 Bastuji-Garin S, Fouchard N, Bertocchi M et al. SCORTEN: a severityof-illness score for toxic epidermal necrolysis. J Invest Dermatol 2000; 115:149–53. 3 Guegan S, Bastuji-Garin S, Poszepczynska-Guigne E et al. Performance of the SCORTEN during the first five days of hospitalization to predict the prognosis of epidermal necrolysis. J Invest Dermatol 2006; 126:272–6. 4 Lebargy F, Wolkenstein P, Gisselbrecht M et al. Pulmonary complications in toxic epidermal necrolysis: a prospective clinical study. Intensive Care Med 1997; 23:1237–44.


中華皮膚科醫學雜誌 | 2004

Ichthyosis Hystrix of Curth - Macklin

Hung-Hsu Yang; Nan-Lin Wu; Yang-Chih Lin; Yu-Hung Wu

Ichthyosis hystrix of Curth-Macklin (IHCM) is an extremely rare keratinization disorder, with verrucous to hystrix-like hyperkeratosis plaques of varying extent. The diagnosis is based on a distinctive pattern of epidermolytic hyperkeratosis and the presence of binucleate cells under light microscopy, as well as unique electron microscopic findings of continuous perinuclear tonofibril shells in the suprabasal keratinocytes. We present the clinical manifestation and light and electron microscopic findings in a 23-year old male patient with IHCM.

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Yu-Hung Wu

Mackay Memorial Hospital

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Hsin-Yi Su

Mackay Memorial Hospital

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Hsiu-Chin Chen

Mackay Memorial Hospital

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Mei-Eng Tu

Mackay Memorial Hospital

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Nan-Lin Wu

Mackay Memorial Hospital

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Pei-Lun Sun

Memorial Hospital of South Bend

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Chyou-Shen Lee

Mackay Memorial Hospital

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Mei-Ing Tu

Mackay Memorial Hospital

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Pa-Fan Hsiao

Mackay Memorial Hospital

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