Yang Park

The importance of maximal airway response to methacholine in the prediction of wheezing development in patients with cough-variant asthma.

Background: A significant proportion of patients diagnosed with cough‐variant asthma eventually manifest classic asthma signs, such as wheezing and dyspnea. The aim of this study was to investigate whether the degree of airway hypersensitivity and/or the level of maximal airway response can predict the development of wheezing in subjects with cough‐variant asthma.

Relationship of wheezing to airflow obstruction in asthmatic children and a history of cough-variant asthma

The aim of this study was to examine the relationship of wheezing to airflow obstruction during acute episodes of asthma in patients who had CVA (cough variant asthma). Two groups of asthmatic children, one group with a past history of CVA (n = 13) and the other group without such a history (n = 14), were followed longitudinally for 12 months. During that time, they were evaluated for the presence of wheezing and the severity of airflow obstruction during acute episodes of asthma. Significant airflow obstruction occurred free of wheezing more frequently, and the presence of clinical wheezing was associated with more severe airflow limitation, in asthmatic patients with a past history of CVA than in those without such a history. We conclude that asthmatic patients who have experienced CVA develop the wheezing symptom at a higher level of airflow obstruction.