Ai Young Lee

Angioblastoma (Nakagawa) : is it the same as tufted angioma ?

Four children affected by intradermal vascular proliferations are presented. The clinicopathological findings closely resemble those of cases described as angioblastoma, a familiar entity in the Japanese literature. Some people suggest that angioblastoma is the same as the tufted angioma described by Wilson‐Jones. We found localized hyperhidrosis in two of our patients. Proliferation of eccrine glands near the tumour lobule was a consistent finding in the biopsy specimens from these four patients. In one patient, some of the vascular tufts were replaced by mucinous material. These findings have not been mentioned in previous reports of tufted angioma.

Pigmented Macules in Patients Treated with Systemic 5-Fluorouracil

Pigmented macules were observed in 72 (52.6%) out of 137 patients treated with systemic 5‐fluorouracil. These pigmented macules usually appeared on the palms and the soles. Their incidence seemed to be proportional to the number of chemotherapy cycles. Histological studies showed a slight increase in melanin pigmentation in the epidermis without any change in the melanocyte number. This suggests that the melanocytes already present produced quantities of melanin.

Lobulated intradermal nevus: Report of three cases

We report the cases of three patients with lobulated intradermal nevi. Biopsy specimens showed similar findings, that is, fatty infiltration within nests of nevus cells, neuroid differentiation of nevus cells, and dermal fibrosis. Our cases probably represent an unusual form of regressing melanocytic nevus.

Provocation Tests in a Chlormezanone-Induced Fixed Drug Eruption

Although as few as seven cases of fixed drug eruption (FDE) due to chlormezanone have been reported, it should not be overlooked as a cause of FDE. To identify the causative agent in FDEs, topical provocation tests are much safer and more convenient than systemic provocation tests. If results of topical provocation tests are reliable, they could become useful diagnostic as well as screening tests. Patch tests were performed in a suspected case of FDE due to chlormezanone on the patients normal and prelesional skin with all ingested drugs whose concentrations were one and ten percent. The base was petrolatum. A positive reaction occurred only at the previously lesional site tested with chlormezanone, and was confirmed with oral provocation tests.