Yannick Quesnel
UCB
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Publication
Featured researches published by Yannick Quesnel.
ChemMedChem | 2014
Joël Mercier; Laurence Archen; Véronique Bollu; Stéphane Carré; Yves Evrard; Eric Jnoff; Benoit Kenda; Bénédicte Lallemand; Philippe Michel; Florian Montel; Florence Moureau; Nathalie Price; Yannick Quesnel; Xavier Sauvage; Anne Valade; Laurent Provins
The role of the synaptic vesicle protein 2A (SV2A) protein, target of the antiepileptic drug levetiracetam, is still mostly unknown. Considering its potential to provide in vivo functional insights into the role of SV2A in epileptic patients, the development of an SV2A positron emission tomography (PET) tracer has been undertaken. Using a 3D pharmacophore model based on close analogues of levetiracetam, we report the rationale design of three heterocyclic non‐acetamide lead compounds, UCB‐A, UCB‐H and UCB‐J, the first single‐digit nanomolar SV2A ligands with suitable properties for development as PET tracers.
Archive | 2004
Benoit Kenda; Philippe Michel; Yannick Quesnel
Archive | 2006
Benoit Kenda; Yannick Quesnel; Ali Ates; Philippe Michel; Laurent Turet; Joël Mercier
Archive | 2008
Benoit Kenda; Laurent Turet; Yannick Quesnel; Philippe Michel; Ali Ates
Archive | 2010
Yannick Quesnel; Laurent Turet; Joël Mercier
Archive | 2006
Célal Ates; Francoise Lurquin; Yannick Quesnel; Arnaud Schule
Archive | 2012
Laurent Provins; Yannick Quesnel
Archive | 2006
Célal Ates; Francoise Lurquin; Yannick Quesnel; Arnaud Schule
Archive | 2006
Benoit Kenda; Yannick Quesnel; Ali Ates; Philippe Michel; Laurent Turet; Joël Mercier
Archive | 2006
Benoit Kenda; Yannick Quesnel; Ali Ates; Philippe Michel; Laurent Turet; Joël Mercier
