Ali Ates

Cerium(IV)-Catalyzed Deprotection of Acetals and Ketals under Mildly Basic Conditions.

Smooth and quantitative deprotection of a wide range of acetals and ketals [Eq. (a); R, R(1)=alkyl, aryl, H] under neutral to mildly basic conditions was achieved with catalytic quantities of cerium ammonium nitrate (CAN). The reaction conditions are compatible with a variety of sensitive functional groups, and aldehydes can be liberated from acetals without being oxidized to the corresponding carboxylic acids.

REMARKABLY EFFICIENT DEPROTECTION OF CYCLIC ACETALS AND KETALS

A simple and mild procedure for the efficient deprotection of cyclic acetals and ketals, using cerium ammonium nitrate (CAN) is reported. The method tolerates a range of functional and protecting groups and is suitable for acid-labile substrates

Neutral, non-racemising, catalytic aerobic oxidation of alcohols

A novel procedure for the catalytic aerobic oxidation of alcohols into carbonyl derivatives under neutral, non-racemising conditions, is reported

Efficient preparation of trisubstituted alkenes using the SmI2 modification of the Julia-Lythgoe olefination of ketones and aldehydes

High yields of di- and tri-substituted alkenes are: obtained by a modification of the Julia-Lythgoe olefination reaction involving the in situ capture of intermediate beta -alkoxy-sulfones by benzoyl or trimethylsilyl chloride, followed by SmI2-mediated reductive elimination. This novel protocol also provides a connective preparation of dienyl ethers, which are important partners in Diels-Alder cycloadditions

Remarkable deprotection of THP and THF ethers catalysed by cerium ammonium nitrate (CAN) under neutral conditions

The catalytic deprotection of a range of functionalised THP and THF ethers can be efficiently performed, under neutral conditions, using as little as 3 mol% CAN in MeCN/borate buffer (pH = 8)

Efficient and convergent stereocontrolled spiroannulation of ketones

Upon treatment with t BuOK/H2O, a variety of omega-halo-beta-keto-ketals undergo smooth cyclisation, affording in excellent yields mono-protected [n,m] spiro bicyclic diketones. This transformation is highly stereoselective producing, in all cases, the diastereoisomerically pure spiro derivatives