Yasuhiko Iino

Unilateral Renal Agenesis Associated with Various Metabolic Disorders in Three Siblings

Unilateral renal agenesis with impaired renal function was found in all 3 siblings of a single family, in association with various metabolic disorders such as diabetes mellitus, hyperuricemia and hyperbilirubinemia with gallstones. The present report suggests that unilateral renal agenesis could occur as a manifestation of a genetic disorder.

Effects of Kinin on Electrolytes Transport and Regulation of Kininase Activity in Distal Nephron Segments of the Rat

It is generally recognized that the cortical collecting duct plays a major role in the fine control of renal sodium excretion, and thus in the regulation of extracellular fluid volume. Several lines of evidence point to the cortical collecting duct as a possible site of kinin action on sodium transport. First, both kallikrein1-3 and kininogen4 have been localized to the collecting duct system. Second, high-affinity binding sites for bradykinin have recently been localized to the cortical and outer medullary collecting ducts5. Third, kinins have a marked inhibitory effect on vasopressin-stimulated water permeability in the isolated, perfused cortical collecting duct of the rabbit. First part of our studies is to investigate whether bradykinin directly affects net sodium transport in the cortical collecting duct of the rat using the isolated, perfused tubule technique.

Long Term Effect of LDL Apheresis in Japan

LDL-apheresis is introduced in many cases all over Japan. Among them, evaluation of long-term effect on ischemic heart disease (IHD) has made on 10 cases with homozygous familial hypercholesterolemia (FH) and 49 cases with heterozygous FH.As to homozygous FH, 3 patients had angina pectoris. Mean duration of treatment was 26 months (52 treatments). The changes in total cholesterol (TC) in each treatment was from 426 mg/dl to 151 mg/dl. Improvement in IHD was observed in 5 out of 10 cases.As to heterozygous FH, 17 cases had history of myocardial infarction and 12 had angina pectoris. Mean duration of treatment was 13 months (19 treatments). Mean TC was decreased from 271 mg/dl to 126 mg/dl by each treatment. Regression in Achilles tendon thickenting or skin and palpebral xanthomas was observed. Frequency of anginal attacks decreased in 8 out of 17 cases. Ischemic change in ECG were improved in 3 out of 26 cases. Coronary angiography performed with 2 to 3 years of interval in some cases revealed regression o...

Effects of Mineralocorticoid on Kininase Activity Along the Distal Nephron Segments of the Rat

The kallikrein-kinin system is known to have natriuretic action in the kidney. What is the rate limiting factor in the action of kinin? Is that the kallikrein activity, kininogen concentration, or kininase activity? There are discrepancies between urinary kallikrein activity and urinary kinin excretion in some reports. Kininogen may not be the rate limiting factor in usual condition because kininogen could be measured in the final urine. In this meaning, kininase can be considered as potential candidate as the rate limiting factor in the kallikrein-kinin system of the kidney.