Yasuko Ogino

Tinuvin® P in a spandex tape as a cause of clothing dermatitis

We report a 54‐year‐old female with allergic Contact dermatitis from 2‐(2‐hydroxy‐5‐methytphenyl) benzotriazole (Tinuvin® P) in a spandex tape sewn into underwear. Tinuvin® P is used us an ultraviolet light absorber for stabilizing plastics and the other organic materials against discoloration and deterioration. It is effective in protecting synthetic and natural fibers, polyesters, chlorinated polyesters, polyvinyls, cellulose acetate, ethyl cellulose, acrylates, dyes, waxes, detergents, cosmetic formulations, etc. Our patient developed itchy erythema on her shoulders, chest and upper back after wearing underwear for I night. She showed positive reactions to spandex tape sewn into the underwear. She also reacted to 2‐(2‐hydroxy‐5‐meihylphenyl)benzotriazole (Tinuvin P), which was contained in the spandex. No cross‐reaction to other benzotriazoles was seen.

Allergic contact dermatitis due to budesonide

Introduced primarily for babies, moist toilet paper is now also used by adults, both to improve hygiene and to control pruritus ani. The main ingredients are water, fragrances, humectants such as sorbitol, glycerin and propylene glycol, preservatives and surfactants. The allergens are the preservatives and the fragrances (I, 2). Most cased are caused by Kathon CG (3). We analyzed 13 types of moist toilet paper (8 brands), and found that all but 3 contained Kathon CG, at from 5.923.4 ppm in the water phase. Patient no. 4 had allergic contact dermatitis from methyldibromoglutaronitrile, one of the active ingredients of the preservative Euxyl K 400. This preservative is a Kathon CG substitute: patient no. 3 had used the same paper brand, which at that time (1988) still contained Kathon CG. Few cases of contact allergy to Euxyl K 400 have yet been reported (4). This case will be expanded on elsewhere (5). We suspect that contact allergy to moist toilet paper is not uncommon, even though few cases SHORT COMMUNICATIONS

Allergic contact dermatitis due to amcinonide

( + / + + ), aluminium subacetate I% aq. (+I++). Later still, the patient was tested intradermally with 0.05 ml aluminium hydroxide (AI(OH)3) in 0.5% sodium chloride, which gave a positive reaction after 1 day which did not disappear until 7 days. 1 month later, we patch tested the patient again with the GIRDCA standard series, using different patch test units (Curates!) and obtained the following positive results: cobalt chloride (+I+ +) and Disperse Yellow 3 (+I++). The history showed that the patient had been exposed to aluminium salts at work; in fact careful enquiry revealed that a component of abrasive products used for burnishing marble consisted mainly (95.2 to 99.2%) of aluminium oxide (Alp3).

Eruptive fibrosarcoma of the skin which developed on the face.

線維肉腫に近い悪性度を示した隆起性皮膚線維肉腫の32歳女性例を報告した。腫瘍発生より5年後初診。左頬に30mm径の紅色軽度隆起性病変を認め, 皮下に下床との可動性に乏しい35×60mm大の不正形硬結を触れた。リンパ節, 全身転移は認めなかった。生検の結果線維肉腫の疑いで腫瘍辺縁より眼の下は12mmその他は15mm離し, 下床は一部骨膜を含み一塊として切除し, 皮膚欠損部には胸三角筋部皮弁を作成し移植した。術後放射線療法と化学療法を施行した。摘出標本で腫瘍は皮下組織, 筋肉内ヘレース状に深く浸潤していた。腫瘍は線維芽細胞様細胞が明瞭なstoriform patternを描き, 核の多形性は少ないが, 核分裂像を多数認めた。現在再発転移なく健在。

A five year study of prognosis of patients with malignant skin tumors at in department of dermatology, Brench Hospital, Nagoya University.

昭和58年～62年の5年間に, 名大分院皮膚科を受診した表皮内癌を含む皮膚悪性腫瘍患者35例について臨床所見, 術後の経過をまとめ考察した。対象とした疾患はボーエン病9例, 日光角化症7例, 乳房外パジェット病1例, 基底細胞上皮腫9例, 有棘細胞癌5例, 悪性黒色腫2例, 皮膚付属器癌1例, 隆起性皮膚線維肉腫1例である。治療は全例に根治的摘出術を行った。63年4月現在4例が死亡した。死因の内訳は老衰2例, 胃癌1例, 原疾患1例で, 原病死は皮膚付属器癌の1例であった。31例は生存しており, そのうち有棘細胞癌の1例に転移を認めたが, その他の症例は全例が再発, 転移無く健在である。