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Yasunobu Asao

Kyoto Pharmaceutical University

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Phytochemistry | 2009

Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak

Toshio Morikawa; Yuanyuan Xie; Yasunobu Asao; Masaki Okamoto; Chihiro Yamashita; Osamu Muraoka; Hisashi Matsuda; Yutana Pongpiriyadacha; Dan Yuan; Masayuki Yoshikawa

The methanolic extract from the pericarps of Sapindus rarak DC. was found to show pancreatic lipase inhibitory activity (IC50=ca. 614 microg/mL). From the extract, oleanane-type triterpene oligoglycosides, rarasaponins I-III (1-3), and raraoside A (4), were isolated together with 13 known saponins and four known sesquiterpene glycosides. Among them, several saponin constituents including rarasaponins I (1, IC50=131microM) and II (2, 172microM), and raraoside A (4, 151microM) inhibited pancreatic lipase activity, which were stronger than that of theasaponin E(1) (270microM).

Chemical & Pharmaceutical Bulletin | 2007

Medicinal Flowers. XII. 1) New Spirostane-Type Steroid Saponins with Antidiabetogenic Activity from Borassus flabellifer

Masayuki Yoshikawa; Fengming Xu; Toshio Morikawa; Yutana Pongpiriyadacha; Seikou Nakamura; Yasunobu Asao; Akira Kumahara; Hisashi Matsuda

Chemical & Pharmaceutical Bulletin | 2007

Medicinal Flowers. XV. The Structures of Noroleanane- and Oleanane-Type Triterpene Oligoglycosides with Gastroprotective and Platelet Aggregation Activities from Flower Buds of Camellia japonica

Masayuki Yoshikawa; Toshio Morikawa; Yasunobu Asao; Emi Fujiwara; Seikou Nakamura; Hisashi Matsuda

Bioorganic & Medicinal Chemistry | 2007

Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa

Hisashi Matsuda; Kazutoshi Yoshida; Katsutoshi Miyagawa; Yasunobu Asao; Saya Takayama; Souichi Nakashima; Fengming Xu; Masayuki Yoshikawa

Biological & Pharmaceutical Bulletin | 2003

Protective Effects of Polygodial on Gastric Mucosal Lesions Induced by Necrotizing Agents in Rats and the Possible Mechanisms of Action

Yutana Pongpiriyadacha; Hisashi Matsuda; Toshio Morikawa; Yasunobu Asao; Masayuki Yoshikawa

Chemical & Pharmaceutical Bulletin | 2009

Antidiabetogenic Constituents from the Thai Traditional Medicine Cotylelobium melanoxylon

Hisashi Matsuda; Yasunobu Asao; Seikou Nakamura; Makoto Hamao; Sachiko Sugimoto; Masako Hongo; Yutana Pongpiriyadacha; Masayuki Yoshikawa

Bioorganic & Medicinal Chemistry Letters | 2006

Nuphar alkaloids with immediately apoptosis-inducing activity from Nuphar pumilum and their structural requirements for the activity

Hisashi Matsuda; Kazutoshi Yoshida; Katsutoshi Miyagawa; Yumiko Nemoto; Yasunobu Asao; Masayuki Yoshikawa

Bioorganic & Medicinal Chemistry Letters | 2003

Potent anti-metastatic activity of dimeric sesquiterpene thioalkaloids from the rhizome of Nuphar pumilum

Hisashi Matsuda; Toshio Morikawa; Mamiko Oda; Yasunobu Asao; Masayuki Yoshikawa

Chemical & Pharmaceutical Bulletin | 2009

Structures of Acetylated Oleanane-Type Triterpene Saponins, Rarasaponins IV, V, and VI, and Anti-hyperlipidemic Constituents from the Pericarps of Sapindus rarak

Yasunobu Asao; Toshio Morikawa; Yuanyuan Xie; Masaki Okamoto; Makoto Hamao; Hisashi Matsuda; Osamu Muraoka; Dan Yuan; Masayuki Yoshikawa

Heterocycles | 2001

New Noroleanane-Type Triterpene Saponins with Gastroprotective Effect and Platelet Aggregation Activity from the Flowers of Camellia Japonica: Revised Structures of Camellenodiol and Camelledionol

Masayuki Yoshikawa; Toshio Morikawa; Emi Fujiwara; Teruki Ohgushi; Yasunobu Asao; Hisashi Matsuda

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Masayuki Yoshikawa

Kyoto Pharmaceutical University

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Hisashi Matsuda

Kindai University

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Toshio Morikawa

Kindai University

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Fengming Xu

Kyoto Pharmaceutical University

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Katsutoshi Miyagawa

Kyoto Pharmaceutical University

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Kazutoshi Yoshida

Kyoto Pharmaceutical University

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Seikou Nakamura

Kyoto Pharmaceutical University

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Emi Fujiwara

Kyoto Pharmaceutical University

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Makoto Hamao

Kyoto Pharmaceutical University

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Masaki Okamoto

Kindai University

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