Yi-Yin Ku

The Use of Lewis Acid in the Reaction of Zinc Salts of Indoles and Acyl Chloride

Abstract 3-Acylindoles have been prepared in 62 – 92% isolated yield from the corresponding indoles and acyl chlorides in the presence of AlCl3.

Cleavage of geminal diacetates using various phenoxides

Abstract Potassium phenoxides (phenoxide, 4-fluorophenoxide, 3-dimethylamino phenoxide) were found to cleave various geminal diacetates and regenerate aldehydes in excellent yields under extremely mild conditions.

A practical synthesis of chiral propargylic alcohols

Abstract A practical and efficient synthesis of chiral propargylic alcohols has been developed starting from inexpensive and readily available chiral methyl lactate. In addition, a regioselective desilylation method was discovered for oxygen deprotection of bis-silylated alkynols having a terminal trimethylsilyl group.

Synthesis of substituted heterocycles. Simple method for the introduction of the N-hydroxyurea functionality

Abstract A simple method for the introduction of the N-hydroxyurea functionality has been developed. This involves conjugate addition of hydroxylamine to a vinylsulfone substrate. This method was successfully used in a facile synthesis of the 5-lipoxygenase inhibitors, zileuton and A-69412.

SYNTHESIS OF A-79175 : A SECOND GENERATION 5-LIPOXYGENASE INHIBITOR

Abstract A convergent, high yielding, and scalable synthesis of A-79175, with a key step involving a mild and efficient CuPd catalyzed coupling reaction of a terminal acetylene with a substituted 2-iodofuran is discussed.

Preclinical Profiling and Safety Studies of ABT-769: A Compound with Potential for Broad-spectrum Antiepileptic Activity

Summary:  Purpose: The objective of this study was to characterize the antiseizure and safety profiles of ABT‐769 [(R)‐N‐(2 amino‐2‐oxoethyl)spiro[2,5]octane‐1‐carboxamide].

Synthesis of the macrolide antibiotic, oxolide

Abstract Oxolide was synthesized from Erythromycin A. Key features include two stereoselective reductions with DIBALH and NaBH3CN and a novel pH dependent purification of the final product. An acid-stable macrolide, oxolide, was synthesized from Erythromycin A. Key features include two stereoselective reductions with DIBALH and NaBH3CN and a simple pH dependent separation of the final product from its C-11 epimer.