Yonghai Hui

Catalytic Asymmetric Synthesis of Quaternary α-Hydroxy Trifluoromethyl Phosphonate via Chiral Aluminum(III) Catalyzed Hydrophosphonylation of Trifluoromethyl Ketones

The chiral hydrogenated tridentate Schiff base-aluminum(III) complex has been first applied in the catalytic enantioselective hydrophosphonylation of trifluoromethyl ketones. The side reactions related to phospha-Brook rearrangement were completely avoided, and the corresponding quaternary α-hydroxy trifluoromethyl phosphonates have been first synthesized in good yields with high enantioselectivities (up to 90% ee).

Chiral biphenylamide derivative: an efficient organocatalyst for the enantioselective synthesis of α-hydroxy phosphonates

The aldol reactions of alpha-keto phosphonates and aldehydes were facilitated by an axially chiral biphenylprolinamide under mild conditions, affording the synthetically and pharmaceutically useful products in high yields and excellent enantioselectivities.