Yoshiaki Kitano

Intrahepatic stones and postoperative choledochoscopy.

SummaryIn 35 out of 38 cases of patients suffering from intrahepatic stones, complete removal of the stones has been carried out with repeated postoperative choledochoscopies, the average being 14.5. A follow-up study revealed that 34 cases remain asymptomatic and are leading a normal social life. The remaining one case died from pancreas carcinoma 22 months after successfully removing the entire stones.With the successful results using postoperative choledochoscopy, we believe that the endoscopy is the prefered approach insofar as it can relieve symptoms, prolong life and render cure in some cases, although it may be only palliative in others.This safer and more reliable procedure as opposed to the blind technique which is carried out under fluoroscopic control should be routinely used for management of intrahepatic stones.

N1-(2 tetrahydrofuryl)-5-fluorouracil (ft-207) in the postoperative adjuvant chemotherapy of gastric cancer. Delivery of a fat-emulsified agent to the lymph

The influence of fat emulsification of N1‐(2‐tetrahydrofuryl)‐5‐fluorouracil (FT‐207) on lymphatic transport was studied in seven postoperative gastric cancer patients. The water‐in‐oil‐type of emulsion of FT‐207 (FT‐w/o), the oil‐in‐water‐type emulsion of FT‐207 (FT‐o/w) and an enteric‐coated granule of FT‐207 (FT‐G) each in 1‐g doses, calculated in terms of FT‐207, were administered orally. Lymph from a thoracic duct fistula, prepared in advance, and from the blood of a peripheral vein was collected simultaneously along a time course after administration to measure the concentrations of FT‐207 and 5‐fluorouracil (5‐FU). For FT‐w/o, FT‐207, and 5‐FU, concentrations were significantly higher, both in the lymph and in the blood, than those for FT‐G and FT‐o/w. However, no significant differences in FT‐207 and 5‐FU concentrations were observed between FT‐o/w and FT‐G. It was concluded that FT‐w/o can be useful as an adjuvant chemotherapeutic drug in the postoperative treatment of gastric cancer.