Yoshio Negishi

Wittig-horner reaction of a phosphonate of reissert analogue a new method for introduction of alkyl groups into isoquinoline

Abstract Dimethyl 2-isopropoxycarbonyl-1, 2-dihydroisoquinoline-1-phosphonate ( 1 ) was prepared from isoquinoline, isopropyl chloroformate, and trimethyl phosphite. Wittig-Horner reaction of 1 with various aldehydes afforded the corresponding exo-methylene compounds, which were converted to 1-substituted isoquinolines with hydrogen chloride.

A new simple synthesis of variously substituted furans and butenolides

The reaction of 1,2-disubstituted 3,3-bis(methylthio)prop-2-en-1-ones with dimethylsulphonium methylide gave 2,2-bis[methylthio]-2,5-dihydrofurans, useful synthons for a variety of furans and butenolides.