Yoshio Sawai

[Mechanism of immunity in intravenous infection of Staphylococcus aureus in mice. 1. Influence of pre-treatment with live cocci, Staphylococcus toxoid or vaccine on the distribution of organisms in the kidney].

マウスに黄色ブドウ球菌の生菌をFreundのincomplete adjuvantとともにあらかじめ皮下接種したのち,1週,2週,3週間後に同菌の生菌を静脈内接種し,日を追つて腎内菌分布および腎膿瘍形成の頻度に及ぼす影響を調べ,次に静脈内接種前18∼24時間に同菌のα-トキソイドあるいはホルマリン死菌ワクチンを生菌処置1週,2週,3週間後のマウスに皮下接種することにより,腎内菌分布および腎膿瘍形成の頻度に及ぼす影響を調べたところ次のような成績を得た。1. 生菌で感作処置したマウスに生菌を静注すると,腎内菌数あるいは腎膿瘍形成の頻度が,無処置の健康マウスに比べて増強する傾向が認められた。2. 生菌感作によるこのような増強は,生菌の静注攻撃前にあらかじめ同菌のα-トキソイドまたはホルマリン死菌ワクチンで前処置しておくことによつて,抑制されることが明らかにされた。また,これらの実験成績に対して若干の考察が加えられた。

Studies on the Mechanism of Immunity in the Intracutaneous Infection of Staphylococcus aureus in Rabbits

After injected intramuscularly with living cells of 2 given strains of Staphylococcus aureus, rabbits were observed for the skin reaction and behavior to intracutaneous infection with the same organism.The sensitized rabbits showed acceleration of the skin reaction. Three weeks after the sensitization, they were challenged intracutaneously by the same staphylococcal strain. In these rabbits, the redness around the abscess was accelerated, whereas the abscess was absorbed more quickly, without showing any ulceration, than in unsensitized controls. A decrease in local reaction and acceleration of recovery occurred in the sensitized rabbits after intravenous injection with vaccine or toxoid.These results suggested that the effect of staphylococcal toxoid might be derived not from the antitoxic effect but from the desensitizing capacity.

[Several cases of an allergy-like disease due to Habu (Trimeresurus flavoviridis) venom as the antigen].

A hypersensitive reaction was observed in three research workers who manage snake venom. Symptoms of those reaction were such as continuous sneezings, serous rhinorrhea, conjunctival itch, dificulty of breething like asthma and general nettle rash. Those hypersensitivity were thought to be induced through inhalation of venom while working in their laboratory. Hypersensitivity appeared within two years in those persons. Steroid, antihistamin and fluid transfusion were effective as treatment.