Yoshiro Honma

Gastrointestinal mucosal cyst of the oral cavity: report of case and review of literature.

The presence of a gastrointestinal cyst or heterotopic mucosa in the oral cavity is a very rare condition. Gorlin and Jirasek reviewed the literature in 1970 and reported 12 cases of cysts containing gastrointestinal mucosa, including one of their own, and two cases of masses of heterotopic gastrointestinal tissue in the oral cavity.’ Following their report, 15 additional cases of gastrointestinal cyst2-12 and three cases of masses of heterotopic gastrointestinal tissues”-” in the oral cavity have been described. This report describes an additional case of this rare condition.

Diagnostic significance of nuclear DNA content and nuclear area in oral hyperplasia, dysplasia, and carcinoma

The nuclear DNA content and the nuclear area in hyperplasia, dysplasia, and carcinoma of the oral cavity were quantitatively analyzed by microspectrophotometry. In carcinoma, marked variability of the nuclear DNA content and the nuclear area was found. The mean nuclear DNA content, the variance of the nuclear DNA content, the frequency of cells above tetraploid (4 C), the mean nuclear area, and the variance of nuclear area in hyperplasia and dysplasia were significantly different from these values with carcinoma. In some cases of leukoplakia and verrucous hyperplasia with subsequent malignant formation, the values were beyond the lower limit of carcinoma. The results suggest that the nuclear DNA and the nuclear area are important objective indices for predicting malignant potential of precancerous lesions.

Postoperative speech function in patients of cancer of floor of mouth with immediate surgical reconstruction. An oncology group study.

根治手術後に即時再建手術を行った口底癌19症例の術後の構音機能と手術との関連性を分析した。評価方法は日本語100語音による発語明瞭度検査である。対象症例の内訳を軟組織の再建方法別にみると, 遊離前腕皮弁移植症例が12例, 大胸筋皮弁移植症例と腹直筋皮弁移植症例がそれぞれ3例, 前腕皮弁と大胸筋皮弁の併用症例が1例であった。舌の切除範囲別では, 舌部分切除症例が14例, 可動部半側切除症例が1例, 半側切除症例が1例, 亜全摘出症例が3例であった。これらの症例について原発腫瘍の大きさ, 切除範囲, 切除様式, 軟組織の再建方法, 下顎骨の再建方法と術後の構音機能の関連について検討した。その結果, 原発腫瘍の大きさによる術後の構音機能の差は少なかったが, 舌の切除範囲が大きくなると構音機能は低下していた。切除様式については側方型の切除を受けた症例の明瞭度は前方型の切除を受けた症例よりも明らかに高く, 切除様式による発音機能の差異が明らかであった。前方型の切除を行った症例の術後の発音障害を防ぐためには, 手術法の改善が必要であり補綴物の応用が有用であることが示唆された。

Clinical evaluation of Granisetron against nausea and vomiting induced by Carboplatin in oral cancer patients. Multi-center study.

カルボプラチン (CBDCA) により誘発される悪心嘔吐に対するグラニセトロンの予防効果を検討する目的で, 多施設による共同研究を実施した。6施設からの30名の口腔癌患者をこの研究の対象とし, 各患者に対しCBDCA (200～350mg/m2) 投与直前にグラニセトロン3mgを静脈内に投与した。悪心嘔吐の発現頻度と, その程度を, 5日間にわたり観察した。悪心は30名中8名に出現したが, 5名の患者ではCBDCA投与当日に軽度の悪心が出現したのみであった。残り3名では2～3日間悪心が継続し, うち1名は3日目に中等度の悪心を訴えた。嘔吐が認められたのは1名のみで, CBDCA投与後第3日目に3回, 第4日目に1回嘔吐した。この患者は第3日目に中等度の悪心を訴えたものと同一の患者であった。本研究の結果, 73.3%の患者で悪心の発現はなく, 96.7%の患者で嘔吐は認められず, 最終効果判定ではグラニセトロンは96.7%の患者において著効, 残りの3.3%は有効と判定された。

Cell kinetic analysis of oral squamous cell carcinoma by using nuclear DNA-RNA contents and antibody to bromodeoxyuridine.

Concerning cell kinetics of oral cancer, the following findings were obtained as a result of both measurement of nuclear DNA-RNA contents, and examination using antiBromodeoxyuridine (BrdU) monoclonal antibody.1. A significant difference was noted between the BrdU labelling index of normal gingival epithelium (2.9±0.5%) and that of oral squamous cell carcinoma (11.4±3.8%) . In the normal epithelium positive identification was restricted to the basal cell layer or the 2nd-3rd supra basal cell layers ; while in squamous cell carcinoma, it was commonly observed to occur around the focus of tumor cells in the well differentiated area, and was seen scattered in the poorly differentiated area.2. No definite relationship was observed between the BrdU labelling index and clinical stages of tumor. With respect to the relationship with histopathological malignancy, the labelling index did not show any association with the grading of differentiation or atypia, but showed positive correlation with the mitotic index. The value of the labelling index was 11.5 times as large as that of mitotic index.3. With the introduction of the BrdU labelling index applied to the results of measurement of nuclear DNA-RNA contents was it admittedly possible to clarify its significance in oral squamous cell carcinoma, a factor which had not been revealed by conventional analyses.