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Dive into the research topics where Yoshitake Naoi is active.

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Featured researches published by Yoshitake Naoi.


Heterocycles | 1990

Stereoselectivities in the coupling reaction between silytated pyrimidine bases and 1-halo-2,3-dideoxyribose

Hiroshi Kawakami; Takashi Ebata; Koshi Koseki; Katsuya Matsumoto; Hajime Matsushita; Yoshitake Naoi; Kazuo Itoh

Coupling reactions between 1-chloro-2,3-dideoxyribose and silylated pyrimidines have been examined from the point of stereoselectivity. When the reaction was carried out in chloroform, the selectivity was in the anomeric ratio of α:β=4:6. On the other hand, the presence of tertiary amine raises the selectivity to α:β=3:7


Heterocycles | 1990

The synthesis of 2'-deoxy-5-trifluoromethyluridine utilizing a coupling reaction

Hiroshi Kawakami; Takashi Ebata; Koshi Koseki; Hajime Matsushita; Yoshitake Naoi; Kazuo Itoh; Nobuhiro Mizutani

The coupling reaction between 1-α-chloro-2-deoxyribose derivative and silylated 5-trifluoromethyluracil was examined. The best stereoselectivity was obtained when the reaction was carried out using a large amount of silylated base in the presence of anhydrous zinc chloride


Heterocycles | 1990

A Method for Easy Preparation of Optically Pure (S)-5-Hydroxy-2-penten-4-olide and (S)-5-Hydroxypentan-4-olide

Koshi Koseki; Takashi Ebata; Hiroshi Kawakami; Hajime Matsushita; Yoshitake Naoi; Kazuo Itoh


Archive | 1990

METHOD OF PRODUCING (S)-4-HYDROXYMETHYL-(GAMMA)-LACTONE

Koshi Koseki; Takashi Ebata; Hiroshi Kawakami; Hajime Matsushita; Kazuo Itoh; Yoshitake Naoi


Heterocycles | 1991

Synthesis of 2',3'-Didehydro-2',3'-dideoxynucleosides Utilizing Coupling Reactions between Nucleic Bases and Phenylthio-substituted 2,3-Dideoxyribose

Hiroshi Kawakami; Takashi Ebata; Koshi Koseki; Katsuya Matsumoto; Hajime Matsushita; Yoshitake Naoi; Kazuo Itoh


Chemistry Letters | 1990

Stereoselectivity in the Coupling Reaction between 2-Phenylthio-2,3-dideoxyribose and Silylated Pyrimidine Bases

Hiroshi Kawakami; Takashi Ebata; Koshi Koseki; Hajime Matsushita; Yoshitake Naoi; Kazuo Itoh


Chemistry Letters | 1989

The synthesis of 2'-deoxyadenosine via stereospecific coupling reaction

Hiroshi Kawakami; Hajime Matsushita; Yoshitake Naoi; Kazuo Itoh; Hajime Yoshikoshi


Archive | 1990

Process for preparing 2'-deoxy-5-trifluoromethyl-beta-uridine

Kazuo Itoh; Yoshitake Naoi; Hajime Matsushita; Takashi Ebata; Hiroshi Kawakami


Chemistry Letters | 1989

Stereoselectivities in the Coupling Reactions between 2-Deoxyribose Derivative and Silylated Adenine

Hiroshi Kawakami; Hajime Matsushita; Makoto Shibagaki; Yoshitake Naoi; Kazuo Itoh; Hajime Yoshikoshi


Archive | 1992

Process for producing 2',3'-dideoxy--g(b)-nucleoside

Kazuo Itoh; Yoshitake Naoi

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