Yoshiya Amemiya

Total synthesis of tylonolide, an aglycone of tylosin

Abstract The total synthesis of tyionolide, a 16-membered-ring aglycone of a macrolide antibiotic, tyiosin, has been accomplished by coupling two segments of C1-C10 and C11-C17 portions, which are stereospecifically derived from D-glucose.

Total synthesis of carbomycin B and josamycin (leucomycin A3)

Abstract The stereospecific total synthesis of macrolide antibiotics, carbomycin B and josamycin (leucomycin A 3 ), is described. The key aglycone has been synthesized by coupling two segments of C1–C10 and C11–C16 portions, which are stereospecifically derived from glucose.

Total synthesis of tylosin

Abstract Tylosin has been synthesized byregio- and stereoselective introduction of the amino disaccharide moiety and D-mycinose onto the previously synthesized 16-membered-ring aglycone.