You-An Ma | Researchain

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Featured researches published by You-An Ma.

ACS Medicinal Chemistry Letters | 2014

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.

Daniel J. Buzard; Sun Hee Kim; Luis Lopez; Andrew M. Kawasaki; Xiuwen Zhu; Jeanne V. Moody; Lars Thoresen; Imelda Calderon; Brett Ullman; Sangdon Han; Juerg Lehmann; Tawfik Gharbaoui; Dipanjan Sengupta; Lorene Calvano; Antonio Garrido Montalban; You-An Ma; Carleton R. Sage; Yinghong Gao; Graeme Semple; Jeff Edwards; Jeremy Barden; Michael M. Morgan; Weichao Chen; Khawja A. Usmani; Chuan Chen; Abu Sadeque; Ronald Christopher; Jayant Thatte; Lixia Fu; Michelle Solomon

APD334 was discovered as part of our internal effort to identify potent, centrally available, functional antagonists of the S1P1 receptor for use as next generation therapeutics for treating multiple sclerosis (MS) and other autoimmune diseases. APD334 is a potent functional antagonist of S1P1 and has a favorable PK/PD profile, producing robust lymphocyte lowering at relatively low plasma concentrations in several preclinical species. This new agent was efficacious in a mouse experimental autoimmune encephalomyelitis (EAE) model of MS and a rat collagen induced arthritis (CIA) model and was found to have appreciable central exposure.

Archive | 2007

Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof

Tawfik Gharbaoui; Sagun K. Tandel; You-An Ma; Marlon V. Carlos; John Robert Fritch

Archive | 2009

PROCESSES FOR THE PREPARATION OF INTERMEDIATES RELATED TO THE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE

Marlon V. Carlos; Ryan O. Castro; Tawfik Gharbaoui; Xiao-Xiong Lu; You-An Ma; Nicholas D. San Martin

Tetrahedron Letters | 2004

One-pot syntheses of 6-mercaptopurines (6MP) from 4,5-diamino-6-chloro-pyrimidines☆

Sagun Tandel; Igor V. Bliznets; Katalin Ebinger; You-An Ma; Dilip Bhumralkar; Mohan Thiruvazhi

Archive | 2011

Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof

Antonio Garrido Montalban; Daniel J. Buzard; John A. Demattei; Tawfik Gharbaoui; Stephen R. Johannsen; Ashwin M. Krishnan; Young Mi Kuhlman; You-An Ma; Michael John Martinelli; Suzanne Michiko Sato; Dipanjan Sengupta

Organic Process Research & Development | 2015

An Efficient Scale-Up Process for the Preparation of the APD334 Precursor 4-Chloromethyl-1-cyclopentyl-2-(trifluoromethyl)benzene

Dipanjan Sengupta; Tawfik Gharbaoui; Ashwin M. Krishnan; Daniel J. Buzard; Robert M. Jones; You-An Ma; Robert Burda; Antonio Garrido Montalban; Graeme Semple

Tetrahedron Letters | 2015

A novel Fischer pseudo-benzylic decarboxylation approach to the 1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl system

Antonio Garrido Montalban; You-An Ma; Steve Johannsen; Sagun K. Tandel; Michael John Martinelli

Archive | 2015

（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス

ガリドモンタルバンアントニオ; Garrido Montalban Antonio; ジョンバザードダニエル; John Buzard Daniel; アルドデマタイジョン; Aldo Demattei John; ガルバウイタウフィック; Gharbaoui Tawfik; ロバートヨハンセンスティーブン; Robert Johannsen Stephen; エム．クリシュナンアシュウィン; M Krishnan Ashwin; ミクハルマンヤング; Mi Khulman Young; マユ−アン; You-An Ma; ジョンマルティネリマイケル; John Martinelli Michael; ミチコサトウスザンヌ; Michiko Sato Suzanne; セングプタディパンジャン; Dipanjan Sengupta

Archive | 2009