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You Qun He

University of Texas Medical Branch

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Featured researches published by You Qun He.

Molecular Pharmacology | 2002

Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Kishore K. Khan; You Qun He; Tammy L. Domanski; James R. Halpert

Biochemistry | 1997

Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis

You Ai He; You Qun He; Grazyna D. Szklarz; James R. Halpert

Chemical Research in Toxicology | 1995

Escherichia coli Expression of Site-Directed Mutants of Cytochrome P450 2B1 from Six Substrate Recognition Sites: Substrate Specificity and Inhibitor Selectivity Studies

You Qun He; You Ai He; James R. Halpert

Chemical Research in Toxicology | 1999

2,2',3,3',6,6'-Hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11

Stephen C. Waller; You Ai He; Greg R. Harlow; You Qun He; Eugene A. Mash; James R. Halpert

Drug Metabolism and Disposition | 2002

Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4.

Kishore K. Khan; You Qun He; Maria Almira Correia; James R. Halpert

Chemical Research in Toxicology | 2002

Substrate Routes to the Buried Active Site May Vary among Cytochromes P450: Mutagenesis of the F−G Region in P450 2B1†

Emily E. Scott; You Qun He; James R. Halpert

Molecular Pharmacology | 2001

Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles.

Margit Spatzenegger; Qinmi Wang; You Qun He; Michael R. Wester; Eric F. Johnson; James R. Halpert

Biochemistry | 2004

An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.

Dmitri R. Davydov; Alexandra E. Botchkareva; Santosh Kumar; You Qun He; James R. Halpert

Journal of Pharmacology and Experimental Therapeutics | 1999

Identification of Selective Mechanism-Based Inactivators of Cytochromes P-450 2B4 and 2B5, and Determination of the Molecular Basis for Differential Susceptibility

Sharon M. Strobel; Grazyna D. Szklarz; You Qun He; Maryam Foroozesh; William L. Alworth; Elizabeth S. Roberts; Paul F. Hollenberg; James R. Halpert

Archives of Biochemistry and Biophysics | 2004

Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix

Emily E. Scott; Hong Liu; You Qun He; Weihua Li; James R. Halpert

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James R. Halpert

University of Texas Medical Branch

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You Ai He

University of Arizona

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Kishore K. Khan

University of Texas Medical Branch

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Emily E. Scott

University of Texas Medical Branch

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Grazyna D. Szklarz

University of Arizona

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Alexandra E. Botchkareva

University of Texas Medical Branch

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Dmitri R. Davydov

University of Montana

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Elizabeth S. Roberts

University of Detroit Mercy

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Eric F. Johnson

Scripps Research Institute

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Eugene A. Mash

University of Arizona

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