Young Mi Kang

Antioxidant effects of fermented sea tangle (Laminaria japonica) by Lactobacillus brevis BJ20 in individuals with high level of γ-GT: A randomized, double-blind, and placebo-controlled clinical study

A randomized, double-blind, and placebo-controlled clinical study was performed to evaluate the antioxidant effects of fermented sea tangle (FST) on healthy volunteers with high levels of γ-glutamyltransferse (γ-GT). Forty-eight participants were divided into a placebo group and an FST group that received FST (1.5 g/day) for 4 weeks. Serum γ-GT, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were determined before and after the trial. Administering FST significantly decreased serum levels of γ-GT and MDA. Additionally, SOD and CAT activities were significantly augmented compared to those in the placebo group after 4 weeks, but no significant alteration was observed in GPx activity compared to that in the placebo group. Our findings indicate that FST enhanced the antioxidant defense system in a healthy population and may be useful as a functional food ingredient.

Protective effect of fermented sea tangle against ethanol and carbon tetrachloride-induced hepatic damage in Sprague-Dawley rats.

Sea tangle has long been used as Korean folk remedy to promote material health, and is one of the popular dietary supplement. This study was designed to evaluate the protective effect of fermented sea tangle (FST) against ethanol and carbon tetrachloride (CCl(4))-induced hepatotoxicity in rats. Sprague-Dawley rats were orally treated with FST (25, 250, 2500 mg/kg/day) with administration of ethanol (5 mL/kg) for 13 weeks and the single intraperitoneal (i.p.) dose of 50% CCl(4) (5 mL/kg/day, CCl(4) in olive oil) at 12 week, and repeated i.p. dose of 20% CCl(4) (2 mL/kg/day) for 1 week. Hepatotoxicity was evaluated by measuring the serum levels of glutamic pyruvate transaminase (GPT), gamma glutamyl transpeptidase (gamma-GT) and malondialdehyde (MDA) as well as the tissue levels of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Ethanol and CCl(4)-induced the rat liver damage, and significantly increased (p<0.05) the GPT, gamma-GT and MDA levels, and decreased the SOD, CAT and GPx levels. However, treatment with FST could decrease serum GPT, gamma-GT, and MDA levels significantly in plasma, and increase the activities of SOD, CAT, and GPx in liver tissues compared with ethanol and CCl(4)-treated group.

Chemical Characterization of Commercial Dark-fleshed Fishes (Mackerel Scomber japonicus, Japanese Spanish mackerel Scomberomorus niphonius, Pacific herring Clupea pallasii) as a Raw Material for Seafood Products

Chemical Characterization of Commercial Dark-fleshed Fishes (Mackerel Scomber japonicus, Japanese Spanish mackerel Scomberomorus niphonius, Pacific herring Clupea pallasii) as a Raw Material for Seafood Products Young Mi Kang1, Sun Young Park1,2, Su Gwang Lee1,2, Jung Suck Lee1, Min Soo Heu1,3 and Jin-Soo Kim1,2* 1Research Center for Industrial Development of Seafood, Gyeongsang National University, Tongyeong 53064, Korea 2Department of Seafood and Aquaculture Science/Institute of Marine Industry, Gyeongsang National University, Tongyeong 53064, Korea 3Department of Food and Nutrition, Gyeongsang National University, Jinju 52828, Korea

Fermented Sea Tangle Attenuates Oxidative Stress in Individuals with a High Level of γ-Glutamyltransferase: a Randomized, Double-Blind, and Placebo-controlled Clinical Study

A randomized, double-blind, placebo-controlled study of fermented sea tangle (FST) was conducted using 48 healthy volunteers with high levels of γ-glutamyltransferase (GGT). Participants (n=48) were divided into a placebo group and a FST group, which consumed FST (1.5 g/day) for 4 weeks. Serum GGT, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Plasma 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), and protein carbonyl contents, which indicate lipid peroxidation, DNA damage, and oxidation of protein, were determined. Decreased serum GGT was found in FST consumption group, compared to the placebo group [mean values (IU/L): 78.71±19.14 and 116.75±38.55, respectively, p<0.001]. Administration of FST significantly (p<0.05) decreased levels of serum AST [mean values (IU/L): 31.08±7.25 and 26.79±6.53 respectively, p<0.001] and ALT [mean values (IU/L): 42.63±18.99 and 31.83±14.21, respectively, p=0.001], compared to the placebo group, and significantly (p<0.05) decreased concentrations of plasma 8-isoprostane, 8-OHdG, and protein carbonyl levels.