Yuji Makino

Controlled Drug Delivery Formulation with Safe Polymers

From the pharmaceutical point of view, the bioavailability, that is the amount and rate of absorption, is the most important factor determining the drug quality with respect to its efficacy and safety. Then, the bioavailability is controlled by well-designed dosage forms, for which interactions with surrounding components are applicable. Practically there are afforded various possibilities of modification of the interaction and then of control of drug delivery by a design of dosage forms, using polymers. The present talk will contain, as example, enteral delivery of insulin by Eudragit microsphere with protease inhibitors, topical mucosal drug delivery systems with adhesive polymers, and nasal delivery of salmon calcitonin by functional powder preparations using microcystalline cellulose. These polymers are guaranteed already as pharmaceutically safe ones.