Yukio Wakimoto
Nagoya City University
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Publication
Featured researches published by Yukio Wakimoto.
Microbiology and Immunology | 2012
Satomi Kani; Yasuhito Tanaka; Kentaro Matsuura; Tsunamasa Watanabe; Hiroshi Yatsuhashi; Etsuro Orito; Ken Inose; Nao Motojuku; Yukio Wakimoto; Masashi Mizokami
IL28B polymorphism is associated with the response to pegylated interferon‐α with ribavirin (PEG‐IFN‐α/RBV) treatment in chronic hepatitis C patients. As a genotyping assay for IL28B single nucleotide polymorphisms (SNPs) in clinical practice, the Invader Plus assay was developed. The accuracy, intra‐assay, inter‐assay precision, and the limit of detection of the Invader Plus assay were evaluated. Two SNPs (rs8099917 and rs12979860) associated with IL28B were genotyped by the Invader Plus and TaqMan assay in 512 Japanese patients. In comparison with direct sequencing, the Invader Plus assay showed 99% accuracy in rs8099917 and 100% accuracy in rs12979860. Intra‐assay and inter‐assay precision were sufficient to use in clinical practice and the detection limit was 1ngDNA/assay. Genotyping by rs8099917 showed that 361 (71%), 144 (28%) and seven (1%) of the patients were major homozygous, heterozygous and minor homozygous types, respectively. Five of the 512 cases (1%) had haplotype differences, but none showed differences between the two genotyping methods. For patients with HCV genotype 1, the prevalence of responders in the major homozygous type was 83.3%, and that of non‐responders in the minor heterozygous/homozygous type was 72.5%. A convenient IL28B genotyping method using the Invader Plus assay could be useful to predict the treatment outcome in clinical practice.
Journal of Infection and Chemotherapy | 2010
Yasuhito Iwashima; Atsushi Nakamura; Haru Kato; Hideaki Kato; Yukio Wakimoto; Naoki Wakiyama; Chiharu Kaji; Ryuzo Ueda
Current Microbiology | 2010
Masaaki Minami; Yukio Wakimoto; Masakado Matsumoto; Hideyuki Matsui; Yasue Kubota; Atsushi Okada; Masanori Isaka; Ichiro Tatsuno; Yasuhito Tanaka; Tadao Hasegawa
The Japanese journal of clinical pathology | 2013
Ohne K; Satomi Kani; Ohashi M; Noboru Shinkai; Takako Inoue; Yukio Wakimoto; Yasuhito Tanaka
Journal of Infection and Chemotherapy | 2013
Masamichi Ogura; Hisako Yano; Mikinori Sato; Atsushi Nakamura; Yukio Wakimoto; Kiyofumi Ohkusu; Takayuki Ezaki
The Journal of the Japanese Association for Infectious Diseases | 2011
Hiroko Wakimoto; Yukio Wakimoto; Hisako Yano; Kousaku Matsubara; Souhei Miyakawa; Atsushi Yoshida; Katsuko Okuzumi; Hiroko Sato; Kyoko Sawada; Yasumasa Yamada; Masahide Futamura; Mariko Kitagawa; Takeshi Sato; Masaaki Minami; Tadao Hasegawa
The Journal of the Japanese Association for Infectious Diseases | 2005
Hiroko Wakimoto; Hisako Yano; Shigeyoshi Baba; Katsuko Okuzumi; Noriko Okamoto; Yukio Wakimoto; Souhei Miyakawa; Masashi Mizokami
The Journal of the Japanese Association for Infectious Diseases | 2008
Hiroko Wakimoto; Masamichi Ogura; Hisako Yano; Akira Koguchi; Yukio Wakimoto; Souhei Miyakawa; Matsuko Doi; Katsuko Okuzumi; Masashi Mizokami
The Journal of the Japanese Association for Infectious Diseases | 2005
Hiroko Wakimoto; Hisako Yano; Shigeyoshi Baba; Katsuko Okuzumi; Noriko Okamoto; Yukio Wakimoto; Souhei Miyakawa; Masashi Mizokami
Archive | 2016
Masaaki Minami; Naoki Wakiyama; Minoru Ohashi; Yukio Wakimoto; Michio Ohta