Zhi-Qian Liu

1‐Acetyl‐3,3‐bis­[3‐(2‐methyl­phen­yl)‐1,2,4‐oxadiazol‐5‐yl]‐1H‐indolin‐2(3H)‐one

The molecular structure of (I) is shown in Fig. 1 and selected bond lengths and angles are given in Table 1. The indanone ring system is planar and the acetyl group at N5 is twisted by 11.8 (2) . The dihedral angle between the O1/N1/ N2/C8/C9 and C1–C6 planes is 9.3 (2) and that between the O4/N3/N4/C22/C23 and C25–C30 planes is 43.9 (1) . Intramolecular C—H N and C—H O hydrogen bonds are observed in the molecular structure. The crystal structure is stabilized by intermolecular C—H O and C—H N hydrogen bonds (Table 2).

Methyl 2-[3-(4-bromophenyl)-1,2,4-oxadiazol-5-ylmethoxy]phenylacetate

1,2,4-Oxadiazole derivatives are of great interest because of their biological properties. Some derivatives of 1,2,4oxadiazole have intrinsic analgesic (Terashita et al., 2002), anti-inflammatory (Nicolaides et al., 1998) and antipicornaviral (Romero, 2001) properties and show high efficacy as agonists [e.g. for muscarinic (Macor et al., 1996), adrenergic (Quagliato & Andrae, 2002) and 5-hydroxytryptamine (Gur et al., 2001)] and antagonists [e.g. for angiotensin (Naka & Kubo, 1999) and adhesion (Juraszyk et al., 1997)] for different receptors. We report here the crystal structure of the title compound, (I).