Zoltán Ot

Lymphatic drainage of the brain

In krassem Gegensatz zur heute herrschenden Auffassung spielt eine Lymphdrainage beim Flüssigkeitskreislauf des Gehirns eine ausschlaggebende Rolle. Werden die zervikalen Lymphbahnen verschlossen, so entsteht eine lymphostatische Enzephalopathie, welche u.a. durch ein Hirnödem, Ganglienzell- und Myelinveränderungen sowie durch Beeinträchtigung der Funktion des Zentralnervensystems gekennzeichnet ist. Es wird ein Durchbruch der Lymphologie in das Gebiet der Neurologie und Neuropathologie gefordert und darauf hingewiesen, dass bei der Pathologie des Hirnödems die Rolle der Lymphzirkulation nicht ausser acht gelassen werden sollte.

Treatment of Experimental Lymphoedema with the Semi-Synthetic Bioflavonoid O-(β-Hydroxyethyl)-Rutosides (HR)

Similar to pantothenic acid and pyridoxine, O-(β -hydroxyethyl)-rutosides (HR) were found to prevent significantly the lymphoedema of the neck and muzzle brought about by surgical lymphatic blockage.

Lymphostatic Retinal Haemangiopathy

Verschluss der zervikalen Lymphbahnen führt zu einer lymphostatischen, retinalen Hämangiopathie mit Verdickung und Strukturveränderung der Basalmembranen.

The Prevention of Lymphostatic Exophthalmus by Pantothenic Acid and Pyridoxine

Lymphostatic Exophthalmus, brought about by cervical lymphatic blockage in the rat, can be treated successfully by the administration of Pantothenic acid and Pyridoxine.

Lipid Storage in Cerebral Pericytes in Lymphogenic Encephalopathy

Intracellular membrane structures are subjected to a continuous renewal. Breakdown products are undoubtedly partly used for resynthesis locally, partly disposed of. The transport of lipoproteins is generally managed by the lymphatics [7]; in the brain, devoid of lymph vessels, prelymphatic pathways (substance of the basement membranes of the blood capillaries → Virchov-Robin’s intraadventitial spaces → intraadventitial spaces of cervical blood vessels → cervical lymphatics; 4) are fulfilling this task. Stasis of lymph-due lipoprotein molecules induces pericytes to incorporate them. In previous histochemical studies performed on the heart muscle, kidney, liver and intestine it has been shown that a regular consequence of lymphostasis is the appearance of ‘invisible’ lipids, derived from breakdown products of desintegrated cellular membrane structures (lipid phanerosis) [2]. The appearance of lipid droplets in pericytes can be regarded as a cerebral equivalent to this lipid phanerosis. In later stages of lymphogenic encephalopathy, collagenous and collagen-like fibers were seen in the substance of basement membranes [3]. Taking into account this fact and the marked alteration in lipid metabolism and the transport described above we feel justified in suspecting that lymphogenic encephalopathy may have some bearings on cerebral artherosclerosis.

Cervical Venous Blockage: Its Failure to Bring About Fine Structural Alterations in the Brain of the Rat in Contrast with Cervical Lymphatic Blockage

In contrast with cervical lymphatic blockage which results in Lymphogenous Encephalopathy, ligation of the jugular veins brings about no alterations in the fine structure of the brain, thus no secondary venous stasis whatsoever plays any role in the pathomechanism of Lymphostatic Encephalopathy; this experimental disease arises as a direct consequence of cervicocerebral lymph stasis.

Volumen- und «Wasseraviditäts»-Bestimmungen im Gehirn bei der lymphogenen Encephalopathie und beim Triaethylzinnsulphat (TZS)-Hirnoedem der Ratte

1. Durch Hirnvolumenbestimmungen Hess sich das Entstehen eines Hirnoedems bei der durch Unterbindung bzw. Resektion der cervikalen Lymphbahnen herbeigefuhrten lymphogenen Encephalopathie der Ratte ern