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Dive into the research topics where Zulfiye Gul is active.

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Featured researches published by Zulfiye Gul.


Food and Chemical Toxicology | 2015

In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile.

Deniz Bagdas; Betul Cam Etoz; Zulfiye Gul; Sedef Ziyanok; Sevda Inan; Ozge Turacozen; Nihal Y. Gul; Ayse Topal; Nilufer Cinkilic; Sibel Tas; Musa Ozgur Ozyigit; Mine Sibel Gurun

Oxidative stress occurs following the impairment of pro-oxidant/antioxidant balance in chronic wounds and leads to harmful delays in healing progress. A fine balance between oxidative stress and endogenous antioxidant defense system may be beneficial for wound healing under redox control. This study tested the hypothesis that oxidative stress in wound area can be controlled with systemic antioxidant therapy and therefore wound healing can be accelerated. We used chlorogenic acid (CGA), a dietary antioxidant, in experimental diabetic wounds that are characterized by delayed healing. Additionally, we aimed to understand possible side effects of CGA on pivotal organs and bone marrow during therapy. Wounds were created on backs of streptozotocin-induced diabetic rats. CGA (50 mg/kg/day) was injected intraperitoneally. Animals were sacrificed on different days. Biochemical and histopathological examinations were performed. Side effects of chronic antioxidant treatment were tested. CGA accelerated wound healing, enhanced hydroxyproline content, decreased malondialdehyde/nitric oxide levels, elevated reduced-glutathione, and did not affect superoxide dismutase/catalase levels in wound bed. While CGA induced side effects such as cyto/genotoxicity, 15 days of treatment attenuated blood glucose levels. CGA decreased lipid peroxidation levels of main organs. This study provides a better understanding for antioxidant intake on diabetic wound repair and possible pro-oxidative effects.


British Journal of Pharmacology | 2016

The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.

Deniz Bagdas; Jenny L. Wilkerson; Abhijit R. Kulkarni; Wisam Toma; Shakir D. AlSharari; Zulfiye Gul; Aron H. Lichtman; Roger L. Papke; Ganesh A. Thakur; M. Imad Damaj

Orthosteric agonists and positive allosteric modulators (PAMs) of the α7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation. Moreover, compounds with dual function as allosteric agonists and PAMs, known as ago‐PAMs, add further regulation of receptor function.


Animal Reproduction Science | 2016

Effect of rainbow trout (Oncorhynchus mykiss) seminal plasma on the post-thaw quality of ram semen cryopreserved in a soybean lecithin-based or egg yolk-based extender.

Burcu Ustuner; Selim Alcay; M. Berk Toker; Zekariya Nur; Elif Gokce; Fusun Sonat; Zulfiye Gul; Muhammed Duman; Cafer Ceniz; Aydın Uslu; Hakan Sagirkaya; M. Kemal Soylu

The aim of the current study was to evaluate the effects of different concentrations of rainbow trout seminal plasma (RTSP) (0.1%, 1% and 10%) in extenders containing either egg yolk or lecithin for use in Awassi ram semen cryopreservation. Pooled sperm were diluted in a two-step dilution method to a final concentration of 1/5 (semen/extender) in egg yolk or lecithin extender containing no RTSP, 0.1%, 1% or 10% RTSP (v/v). Semen samples were assessed for sperm motility, plasma membrane integrity [hypoosmotic swelling test (HOST) and Hoechst 33258] and defective acrosomes [FITC-conjugated Pisum sativum agglutinin (PSA-FITC)] at the following five time points: after dilution with extender A; after equilibration; and post-thaw at 0h, 3h and 5h. Malondialdehyde (MDA) was examined only after thawing. Freezing and thawing procedures (dilution, equilibration and post-thaw incubation at 0h, 3h and 5h) negatively affected the motility (P<0.001) and acrosome integrity (P<0.001). Additionally, freezing and thawing negatively affected the plasma membrane integrity, as determined by the HOST and Hoechst 33258 (P<0.001). The extender group affected the motility (P<0.001) and the HOST results (P<0.001). Levels of MDA in the egg yolk extender with 1% RTSP group were significantly lower than in the lecithin control group (P<0.05). In conclusion, the egg yolk extender groups that were supplemented with 10% and 1% RTSP provided greater cryoprotective effects for semen survivability during 5h incubation than the other extender groups.


Annals of Plastic Surgery | 2016

Chlorogenic Acid Enhances Abdominal Skin Flap Survival Based on Epigastric Artery in Nondiabetic and Diabetic Rats.

Deniz Bagdas; Betul Cam Etoz; Zulfiye Gul; Musa Ozgur Ozyigit; Nilufer Cinkilic; Sevda Inan; Naciye Isbil Buyukcoskun; Kasim Ozluk; Mine Sibel Gurun

AbstractPrevious studies showed that chlorogenic acid (CGA) accelerates wound healing via its antioxidant activity. We aimed to investigate the effect of CGA in an experimental epigastric abdominal skin flap model in nondiabetic and diabetic rats. Rats were firstly divided into 2 groups: nondiabetic and diabetic. Diabetes was induced by streptozotocin. Then, 4 subgroups were created for each group: vehicle as well as 0.2 mg/0.5 mL, 1 mg/0.5 mL, and 5 mg/0.5 mL CGA treatments. Right epigastric artery–based abdominal skin flaps were elevated and sutured back into their original position. Chlorogenic acid or vehicle was injected once into the femoral arteries by leaving the epigastric artery as the single artery feeding the flaps during the injection. On postoperative day 7, flap survivals were evaluated, and the rats were killed. Distal flap tissues were collected for histopathological and biochemical assays. Chlorogenic acid showed greater flap survival in both nondiabetic and diabetic rats. Capillary density was increased, and necrosis was reduced in the CGA-treated rats. Chlorogenic acid decreased malondialdehyde levels as well as increased reduced glutathione and superoxide dismutase levels in the flap tissues. This study showed that CGA significantly improved flap survival by its antioxidant activities with intra-arterial local injections.


Biological & Pharmaceutical Bulletin | 2014

Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Deniz Bagdas; Betul Cam Etoz; Sevda Inan Ozturkoglu; Nilufer Cinkilic; Musa Ozgur Ozyigit; Zulfiye Gul; Naciye Isbil Buyukcoskun; Kasim Ozluk; Mine Sibel Gurun


Naunyn-schmiedebergs Archives of Pharmacology | 2014

Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing

Deniz Bagdas; Nihal Y. Gul; Ayse Topal; Sibel Tas; Musa Ozgur Ozyigit; Nilufer Cinkilic; Zulfiye Gul; Betul Cam Etoz; Sedef Ziyanok; Sevda Inan; Ozge Turacozen; Mine Sibel Gurun


Neurochemical Research | 2016

Protective Effects of Chlorogenic Acid and its Metabolites on Hydrogen Peroxide-Induced Alterations in Rat Brain Slices: A Comparative Study with Resveratrol

Zulfiye Gul; Celaleddin Demircan; Deniz Bagdas; Rifat Levent Buyukuysal


Cryobiology | 2016

Freeze-dried egg yolk based extenders containing various antioxidants improve post-thawing quality and incubation resilience of goat spermatozoa

Selim Alcay; Elif Gokce; M. Berk Toker; N. Tekin Onder; Burcu Ustuner; Ender Uzabaci; Zulfiye Gul; Seda Cavus


Neurochemical Research | 2014

High Glutamate Attenuates S100B and LDH Outputs from Rat Cortical Slices Enhanced by Either Oxygen–Glucose Deprivation or Menadione

Celaleddin Demircan; Zulfiye Gul; R. Levent Büyükuysal


Uludağ Üniversitesi Veteriner Fakültesi Dergisi | 2014

Tavşanlarda Orta Dönem Gebeliklerin Sonlandırılmasında Kullanılan Aglepriston'un Bazı Oksidatif Stres Parametreleri Üzerine Etkisi

Fusun Sonat; Deniz Bağdaş; Zulfiye Gul; Gözde Rabia Özalp

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