Zuxing Chen

Gewald synthesis of 2-aminothiophenes on a soluble polymer-support

A variety of polysubstituted thiophenes have been prepared via a solvent-free one-pot microwave assisted Gewald reaction using poly (ethylene glycol) as a soluble polymer support.

NOVEL SYNTHESIS OF MONOETHERS OF HYDROQUINONE AND RESORCINOL ON SOLUBLE POLYMER-SUPPORTS

ABSTRACT Monoethers of hydroquinone and resorcinol were easily prepared using PEG as soluble polymer-supports, monoprotection group and phase transfer catalyst with good yields and high selectivity of functionlization in homogenous solution.

Synthesis of Methyl N‐Aryl Oxamate Using Soluble Polymer Support

Abstract A variety of methyl N‐aryl oxamates were synthesized using poly(ethylene glycol) (PEG) as a soluble polymer support and a monoproctection group with excellent yields.

Soluble Polymer-Supported Synthesis of α-Amino Acid Derivatives

Abstract A practical and efficient synthesis of N-substituted α-amino acid derivatives on soluble polymer support is described.

Soluble Polymer-Supported Synthesis of Tertiary Amines

Abstract The synthesis of tertiary amines on a modified soluble polymer, poly(ethylene glycol) (PEG), is described. The PEG-bound quaternary intermediates were assembled via Michael addition reaction, followed by alkylation. Cleavage from the soluble polymer support was induced by insoluble weak basic resin, to afford the target tertiary amines in excellent purity.

Synthesis of non-cross-linked polystyrene supported (4 S )-4-substituted-4,5-dihydrooxazoline

From N-Boc L-tyrosine ethyl ester, we synthesised (4S)-4-[4-(4-vinylbenzyloxy)benzyl]-4,5- dihydrooxazoline, which was copolymerized with styrene to obtain non-cross-linked polystyrene supported 2-hydrogen oxazoline in 29.4% yield.

Synthesis of non-cross-linked polystyrene supported 5,5-dimethyl oxazolidinone chiral auxiliary

A new chiral auxiliary, non-cross-linked polystyrene supported 5,5-dimethyl oxazolidinone was synthesised in 25.1% yield using L-tyrosine as the starting material using a six-step method.

Synthesis of a new chiral auxiliary: non-cross-linked polystyrene bound (4S)-oxazolidine-2-thione

A new chiral auxiliary, non-cross-linked polystyrene bound (4S)-oxazolidine-2-thione, was synthesised from L-tyrosine in 24.2% by a seven step method.

Asymmetric synthesis of both ( R )-and ( S )-arundic acid

The asymmetric synthesis of both (R)-and (S)-arundic acid has been achieved via the key step of a stereoselective alkylation reaction using non-cross-linked polystyrene (NCPS) supported (4R)- and (4S)-2-phenylimino-2-oxazolidine as chiral auxiliaries. This method is efficient (both enantiomers were obtained in 99% ee and 60% overall yield) and the chiral auxiliaries can be recovered quantitatively by simple filtration.

A new process for the synthesis of ( 2S , 3S )-2-ethyl-3-methylvaleramide

A new process for synthesis of (2S,3S)-2-ethyl-3-methylvaleramide has been developed via the key step of a diastereoselective alkylation reaction using non-cross-linked polystyrene (NCPS) supported (4S)-2-phenylimino-2-oxazolidine as a chiral auxiliary. This method is efficient with the target product obtained in 99.24% ee and 38.4% overall yield and the chiral auxiliaries can be recovered quantitatively by simple filtration.